Results 131 to 140 of about 4,042,650 (303)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
The Two Tales of Forced Labour: Katorga and Reformed Prison in Imperial Russia (1879-1905)
Almanack: This article explores the advance of the prison reform in the Russian Empire. It examines the governmental department that was the driver of this reform, the Main Prison Administration, and focuses on its policy in the domain of the forced labour of ...
Zhanna Popova
doaj +1 more source
THE SYSTEMIC APPROACH TO NATIONAL INNOVATION SYSTEMS IN A KNOWLEDGE-BASED ECONOMY [PDF]
The aim of this paper is to present the concept of National InnovationSystems, their history and role in the understanding of a systemic approach to research,development and innovation at national and global level.
Ioan Moise Achim, Teodora Popescu
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
8. Road to World War II (1931-1939)
, 1958 In the history of international relations, the 1920\u27s are characterized by tidying up after the war to make the world safe for democracy; the 1930\u27s, by preparations for World War II.
Bloom, Robert L. +6 more
core
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
What Determines Immigration's Impact? Comparing Two Global Centuries [PDF]
Can history shed light on the modern debate about immigration%u2019s labor market impact in high wage economies? This paper examines the relationship between migration and capital flows in the age of mass migration before 1914, the so-called first global
Jeffrey G. Williamson, Timothy J. Hatton
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source