Results 201 to 210 of about 9,417,861 (245)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Global Burden of Secondhand Smoke-Attributable ER-Negative Breast Cancer and Exploratory Immune-Metabolic Mediation Using Mendelian Randomization. [PDF]

Int J Womens Health
Yang D, Shang F, Ma X, Zhang H, Ren X, Luan X, Wang J, Li Y, Wu T, Lv D, Yan Y, Liu J, Xu Y.   +12 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Research intensity for neglected tropical diseases and other infectious diseases before and after the COVID-19 pandemic. [PDF]

J Glob Health
Komorizono R, Tamaki R, Fujita N, Hamada M, Suzuki K, Kaneko S, Furuse Y.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Food systems performance evaluated against targets and benchmarks reveals urgent gaps and a path to 2050. [PDF]

Nat Food
Carducci B, Schneider Lecy K, Nordhagen S, Beal T, Béné C, Gonzalez Fischer C, Herforth A, Tubiello FN, Ambikapathi R, Arunkumar K, Campeau C, Dasgupta S, DeClerck F, Del Pino Álvarez I, Guarín A, McLaren R, Vivero-Pol JL, Aburto N, Barquera S, Battersby J, Cafiero C, Conforti P, Caron P, Cattaneo A, Covic N, Elouafi I, Fabi C, Gephart JA, Fremier A, Foley P, Golden CD, Hendriks SL, Huang J, Kennedy G, Laar A, Lal R, Lidder P, Loken B, Malapit H, Marshall Q, Masuda YJ, Remans R, Resnick D, Saisana M, Sumaila UR, Torero Cullen M, Webb P, Wiebe K, Haddad L, Rosero Moncayo J, Fanzo J, Herrero M.   +51 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

A comparative "report card" wellbeing assessment of 22 countries in the Global Flourishing Study. [PDF]

Discov Glob Soc
Lomas T, Padgett RN, Ritchie-Dunham JL, Cowden RG, Chung CA, Nilsson AH, Case BW, Chen Y, Felton C, Makridis CA, Lee MT, Johnson BR, VanderWeele TJ.   +12 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

An Evaluation Method for Influential Nodes Based on Multi-Attribute Neighbor Contributions in Complex Networks. [PDF]

Entropy (Basel)
Zhao N, Dai C, Yang G, Luo T, Xiong N, Wang J.   +5 more
europepmc   +1 more source