Results 71 to 80 of about 6,683,240 (331)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Justice for All: The Struggle for Worker Rights in Mexico [PDF]

, 2003
[Excerpt] The Solidarity Center is launching a new series, Justice for All: The Struggle for Worker Rights. This series follows the May 2003 publication of the Solidarity Center’s groundbreaking Justice for All: A Guide to Worker Rights in the Global ...
Compa, Lance A
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Protection of Linguistic Diversity & Access to Justice for All through Pro Bono: Case Study of Nigeria (International Federation of Women Lawyers & Nigerian Law School Law Clinics)

International Journal of Clinical Legal Education
Access to justice for the indigent in Nigeria has been a growing concern over the years and has drawn governmental and private efforts towards achieving this feat.
Rebecca E. Badejogbin
doaj   +1 more source

The \u3cem\u3eLancet\u3c/em\u3e Commission on Global Health Law: The Transformative Power of Law to Advance the Right to Health [PDF]

, 2019
A new report by The Lancet-O’Neill-Georgetown University Commission on Global Health and the Law shows how law can fulfill the global pledge of the human right to health, while “leaving no one behind.” I call this “global health with justice.” We need ...
Gostin, Lawrence O.
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Method development for an untargeted HS-SPME-GC–MS analysis of terpenes and cannabinoids for the geographical sourcing of Marijuana

Talanta Open
Despite growing decriminalization of Cannabis sativa (i.e., marijuana) possession throughout the United States of America, there remains to be an ongoing interest in the detection of unlawfully possessed and transported marijuana. This issue has resulted
Janet Crespo Cajigas, Vidia A. Gokool, Howard K. Holness, Kenneth G. Furton, Lauryn E. DeGreeff   +4 more
doaj   +1 more source

Global Civil Justice

SSRN Electronic Journal
Lo studio affronta comparativamente i sistemi europei e anglo-americani della giustizia civile, evidenziando i punti in comune e introducendo il concetto di global civil justice come modello nuovo di ricerca e insegnamento.
openaire   +2 more sources

Toward a Vision of Sexual and Economic Justice [PDF]

, 2009
This report is based on the Virginia C. Gildersleeve Lecture and colloquium at Barnard College, with keynote speakers Josephine Ho and Naomi Klein. The participants in the colloquium have all made significant contributions to our understandings of global
Janet R. Jakobsen, Kate Bedford
core