Results 271 to 280 of about 453,853 (394)

2D/3D CMR tissue tracking versus CMR tagging in the assessment of spontaneous T2DM rhesus monkeys with isolated diastolic dysfunction [PDF]

, 2018
et al,, Zheng, Jie
core   +1 more source

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Global Longitudinal Strain in Stress Echocardiography: A Review of Its Diagnostic and Prognostic Role in Noninvasive Cardiac Assessment. [PDF]

Diagnostics (Basel)
Antoniou N, Iliopoulou S, Raptis DG, Grammenos O, Kalaitzoglou M, Chrysikou M, Mantzios C, Theodorou P, Bostanitis I, Charisopoulou D, Koulaouzidis G.   +10 more
europepmc   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Clinico-imaging profile and correlations of global longitudinal strain abnormalities in Indian hypertrophic cardiomyopathy patients. [PDF]

Indian Heart J
Mantoo MR, Seth S, Naik N, Jagia P, Yadav S, Yadav R.   +5 more
europepmc   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Intraoperative global longitudinal strain and strain rate as predictors of unfavorable outcome following on-pump mitral surgery: a prospective observational study. [PDF]

J Anesth Analg Crit Care
Monaco F, Bonaccorso A, D'Andria Ursoleo J, Pruna A, Lerose CC, Di Prima AL, Barucco G, Landoni G, Licheri M, Mit-Go Study Group Collaborators.   +9 more
europepmc   +1 more source

Effect of atrial fibrillation ablation on myocardial function: insights from cardiac magnetic resonance feature tracking analysis [PDF]

, 2013
Armbruster, M, Boubertakh, R, Ceelen, F, Hunter, RJ, Petersen, SE, Schilling, RJ, Sommer, WH   +6 more
core   +1 more source

Global Longitudinal Strain and Cardiac Events in Patients With Immune Checkpoint Inhibitor-Related Myocarditis.

Journal of the American College of Cardiology, 2020
Magid Awadalla, Syed S Mahmood, J. Groarke, Malek Z O Hassan, A. Nohria, Adam Rokicki, Sean P. Murphy, N. Mercaldo, Lili Zhang, Daniel A. Zlotoff, K. Reynolds, R. Alvi, D. Banerji, Shiying Liu, L. Heinzerling, Maeve Jones-O’Connor, Rula Bany Bakar, J. Cohen, M. Kirchberger, R. Sullivan, Dipti Gupta, Connor P. Mulligan, Sachin P. Shah, S. Ganatra, M. Rizvi, G. Sahni, C. Tocchetti, D. Lawrence, M. Mahmoudi, R. Devereux, Brian J. Forrestal, Anant Mandawat, A. Lyon, Carol L Chen, A. Barac, J. Hung, P. Thavendiranathan, M. Picard, F. Thuny, S. Ederhy, M. Fradley, T. Neilan   +41 more
semanticscholar   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source