Results 71 to 80 of about 82,136 (245)

Global Mean Sea Level Changes to ENSO‐Related Regional Land Water Storage

Geophysical Research Letters
The 2010–2011 La Niña caused a sharp but temporary drop in global sea level due to increased rainfall and terrestrial water storage primarily in Australia. However, whether similar responses occurred in other La Niña events remains unclear.
Huazhen Li, Andréa S. Taschetto, Alex Sen Gupta, Caroline C. Ummenhofer   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The rate of global sea level rise doubled during the past three decades

Communications Earth & Environment
The rise in globally averaged sea level—or global mean sea level—is one of the most unambiguous indicators of climate change. Over the past three decades, satellites have provided continuous, accurate measurements of sea level on near-global scales. Here,
B. D. Hamlington, A. Bellas-Manley, J. K. Willis, S. Fournier, N. Vinogradova, R. S. Nerem, C. G. Piecuch, P. R. Thompson, R. Kopp   +8 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Global Mean and Relative Sea-Level Changes Over the Past 66 Myr: Implications for Early Eocene Ice Sheets

Earth Science, Systems and Society
We estimate ice-volume driven (barystatic; BSL) sea-level changes for the Cenozoic using new Mg/Ca data from 58 to 48 Ma and a revised analysis of Mg/Ca trends over the past 66 Myr.
K. G. Miller, W. J. Schmelz, J. V. Browning, Y. Rosenthal, A. V. Hess, R. E. Kopp, J. D. Wright   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Assessment of Sea Level Rise at West Coast of Portugal Mainland and Its Projection for the 21st Century

Journal of Marine Science and Engineering, 2019
Based on the updated relative sea level rise rates, 21st-century projections are made for the west coast of Portugal Mainland. The mean sea level from Cascais tide gauge and North Atlantic satellite altimetry data have been analyzed.
Carlos Antunes
doaj   +1 more source

Year by year closure adjustment of global mean sea level budget, inclusive of lumped snow, water vapor, and permafrost mass components

Journal of Geodetic Science, 2020
Global mean sea level budget is rigorously adjusted during the period 2005–2015 with an emphasis on closing the budget on a year by year basis as opposed to using linear trends of global mean sea level components.
Iz H. Bâki, Shum C. K.
doaj   +1 more source