Results 31 to 40 of about 480,221 (262)

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Weaker Association Between Financial Security and Health in the Global South

Societies
Background: Subjective socioeconomic status (SES) is a powerful determinant of health and well-being, capturing individuals’ perceptions of their material conditions and security.
Shervin Assari
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Real-time prediction of intradialytic relative blood volume: a proof-of-concept for integrated cloud computing infrastructure

BMC Nephrology, 2021
Background Inadequate refilling from extravascular compartments during hemodialysis can lead to intradialytic symptoms, such as hypotension, nausea, vomiting, and cramping/myalgia.
Sheetal Chaudhuri, Hao Han, Caitlin Monaghan, John Larkin, Peter Waguespack, Brian Shulman, Zuwen Kuang, Srikanth Bellamkonda, Jane Brzozowski, Jeffrey Hymes, Mike Black, Peter Kotanko, Jeroen P. Kooman, Franklin W. Maddux, Len Usvyat   +14 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A formative research to explore the programmatic approach of vaccinating the Rohingya refugees and host communities against COVID-19 infection in Bangladesh

BMC Health Services Research, 2023
Background The vaccination of the Rohingya refugees and host communities against COVID-19 in Cox’s Bazar started in August 2021. Government authorities and Non-Government Organisation partners implemented a project around the initial period of ...
Anika Tasneem Chowdhury, Satyajit Kundu, Zeeba Zahra Sultana, Heba Hesham Ali Hijazi, Ahmed Hossain   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Energy Poverty in the Era of Climate Change: Divergent Pathways in Hungary and Jordan

Urban Science
This study examines the interrelated challenges of climate change and energy poverty across two distinct industrial regions: Borsod-Abaúj-Zemplén in Hungary and Zarqa in Jordan. Both areas face unemployment and low-income levels, as well as environmental
Mohammad M. Jaber, Eszter Siposné Nándori, Katalin Lipták   +2 more
doaj   +1 more source

Students with global experiences during medical school are more likely to work in settings that focus on the underserved: an observational study from a public U.S. institution

BMC Medical Education, 2021
Background Global health interest has grown among medical students over the past 20 years, and most medical schools offer global health opportunities.
Shay E. Slifko, Nadja A. Vielot, Sylvia Becker-Dreps, Donald E. Pathman, Justin G. Myers, Martha Carlough   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source