Results 31 to 40 of about 38,860 (261)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Sea level rise already delays coastal commuters
Environmental Research: Climate, 2023 Although the most dire societal impacts of sea-level rise (SLR) typically manifest toward the end of the 21st century, many coastal communities face challenges in the present due to recurrent tidal flooding.
Mathew E Hauer +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Journal of Politics in Latin AmericaHow do religiosity, populism, ideology, and gender independently and interactively shape Latin American legislators’ attitudes towards gender equality?
Nina Wiesehomeier, Asbel Bohigues
doaj +1 more source
Editorial: Novel Perspectives on Status in Global Politics
Politics and GovernanceThis thematic issue advances debates on status in international relations (IR) by integrating novel empirical research with innovative theoretical perspectives.
Ali Bilgic +2 more
doaj +1 more source
, 2019 Over the past three decades, trade with low-wage countries - in first place China - has grown dramatically. Economic theory has long recognized that trade liberalization, though enlarging the overall economic pie, also produces strong redistributive effects: while it increases aggregate productivity and benefits consumers through lower prices and ...
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
GLOBAL SYSTEM ANALYSIS AND THE FORECAST OF THE FUTURE [PDF]
Journal of Defense Resources Management, 2019 Starting from the creation of our humanity till the present day the world order has changed dramatically. The world transformation starting from individual groups, tribes, kingdoms, countries, empires, colonies, federations, republics, and in order to ...
Agshin BABAYEV
doaj
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source