Results 81 to 90 of about 717,076 (357)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

System aspects of spacecraft charging [PDF]

open access: yes, 1977
Satellites come in a variety of sizes and configurations including spinning satellites and three-axis stabilized satellites. All of these characteristics have a significant effect on spacecraft charging considerations.
Bower, S. P.
core   +1 more source

Positioning system of the ANTARES Neutrino Telescope

open access: yes, 2009
Completed in May 2008, the ANTARES neutrino telescope is located 40 km off the coast of Toulon, at a depth of about 2500 m. The telescope consists of 12 detect or lines housing a total of 884 optical modules.
Brown, Anthony M.
core   +2 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Spacecraft applications of advanced global positioning system technology [PDF]

open access: yes
The purpose of this study was to evaluate potential uses of Global Positioning System (GPS) in spacecraft applications in the following areas: attitude control and tracking; structural control; traffic control; and time base definition (synchronization).
Austin, Richard   +5 more
core   +1 more source

Relativistic Positioning Systems

open access: yes, 2006
The theory of relativistic {\em location systems} is sketched. An interesting class of these systems is that of relativistic {\em positioning systems,} which consists in sets of four clocks broadcasting their proper time.
Coll, Bartolomé
core   +4 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

A turn-key Concept for active cancellation of Global Positioning System L3 Signal [PDF]

open access: yes, 2010
We present a concept, developed at the National Astronomy and Ionosphere Center (NAIC) at Arecibo, Puerto Rico, for active suppression of Global Positioning System (GPS) signals in the 305 m dish radio receiver path prior to backend processing.
Edgar, Clyde   +6 more
core   +1 more source

Navigation in Antarctica Today: The Global Positioning System [PDF]

open access: yes
This site contains information that students use to investigate the use of the Global Positioning System (GPS) in Antarctica and across the globe. They conduct research on the Web to understand how and why GPS is used today. They also complete a hands-on

core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

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