Results 61 to 70 of about 1,312,704 (343)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Global outlook on sustainable consumption and production policies: taking action together [PDF]

, 2012
Provides a non-exhaustive review of policies and initiatives that are promoting the shift towards sustainable consumption and production (SCP) patterns. This report identifies examples of effective policies and initiatives being implemented worldwide.

core  

Global Spatially-Disaggregated Crop Production Statistics Data for 2010 Version 2.0

, 2019
Using a variety of inputs, IFPRI's Spatial Production Allocation Model (SPAM) uses a cross-entropy approach to make plausible estimates of crop distribution within disaggregated units. Moving the data from coarser units such as countries and sub-national
International Food Policy Research Institute (IFPRI)
core   +1 more source

Strategic Coupling and Its Impact on the Survival of Taiwan-Invested Enterprises in Chinese Mainland: A Configuration-Based Perspective

Redai dili
This study analyzes the factors influencing the exit of Taiwanese direct investment (TDI) enterprises from Chinese mainland by quantitatively measuring location advantage and spatial stickiness, the two core variables of strategic coupling.
Sun Jiping, Wei Suqiong, You Xiaojun, Chen Jindong   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Global Spatially-Disaggregated Crop Production Statistics Data for 2000 Version 3.0.7

, 2019
Using a variety of inputs, IFPRI's Spatial Production Allocation Model (SPAM) uses a cross-entropy approach to make plausible estimates of crop distribution within disaggregated units. Moving the data from coarser units such as countries and sub-national
International Food Policy Research Institute
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Global Spatially-Disaggregated Crop Production Statistics Data for 2005 Version 3.2

, 2016
Using a variety of inputs, IFPRI's Spatial Production Allocation Model (SPAM) uses a cross-entropy approach to make plausible estimates of crop distribution within disaggregated units. Moving the data from coarser units such as countries and sub-national
International Institute for Applied Systems Analysis (IIASA), International Food Policy Research Institute (IFPRI)   +1 more
core   +1 more source

Charting the course for the next decade of sustainability research and innovation

Global Sustainability
Non-technical summary The Anthropocene era demands urgent societal changes as we exceed planetary limits. Addressing key sustainability and governance challenges requires inter- and transdisciplinary approaches.
G. B. Sioen, S. McGreevy, J. Ungvari, F. Attig-Bahar, S. Juhola   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source