Results 51 to 60 of about 194,273 (258)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Correction: Bearing Witness: Témoignage as a Tool for Child Advocacy during Armed Conflict.
PLOS Global Public Health[This corrects the article DOI: 10.1371/journal.pgph.0004947.].
PLOS Global Public Health Editors
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
PLOS Global Public Health[This corrects the article DOI: 10.1371/journal.pgph.0003286.].
PLOS Global Public Health Staff
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Global Public Health and the Academy
American Journal of Pharmaceutical Education, 2006 There is no shortage of disease and related sequelae in the United States for our collective focus in research, teaching, and service roles in schools and colleges of pharmacy. The prevalence of cardiovascular disease, cancer, and infectious diseases require the expertise of physicians, pharmacists, and a myriad of health professionals for prevention ...
openaire +3 more sources
Curricular Models and Learning Objectives for Undergraduate Minors in Global Health
, 2020 Background: A growing number of institutions of higher education offer undergraduate educational programs in global health. Objective: To identify all undergraduate minors in global health being offered in the United States during the 2019–20 academic ...
Waggett, Caryl E. +3 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
CDC global health strategy [PDF]
The vision of CDC\u2019s global heath strategy is a world where people live healthier, safer, and longer lives through science, policy, partnership, and evidence-based public health action.For 60 years, CDC has provided domestic and global public health ...
core +2 more sources