Results 31 to 40 of about 241,695 (296)

From opt-in to obligation? : Examining the regulation of globally operating tech companies through alternative regulatory instruments from a material and territorial viewpoint [PDF]

, 2020
Modern society’s ever-increasing reliance on technology raises complex legal challenges. In the search for an efficient and effective regulatory response, more and more authorities – in particular the European Union – are relying on alternative ...
Vander Maelen, Carl
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Regulatory Governance: Rules, Resistance and Responsibility [PDF]

, 2018
Regulatory governance frameworks have become essential building blocks of world society. From supply chains to the regimes surrounding international organizations, extensive governance frameworks have emerged which structure and channel a variety of ...
Kjaer, Poul F., Vetterlein, Antje
core  

The Need for Revised Resolution Regimes and Supervisory Arrangements [PDF]

, 2011
In October 2010, having drawn crucial lessons fom the Financial Crisis which was triggered in 2007, and whose impact was still evident at the time, the Financial Stability Board Recommendations on systemically important financial institutions „called ...
Ojo, Mariane.B.
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Decarbonization in Antarctic tourism: integrating the global sectoral and regional regimes

Frontiers in Marine Science
With Antarctic tourism gaining increasing popularity in the twenty-first century, decarbonization in Antarctic tourism shows a growing importance. The challenge of decarbonizing Antarctic tourism lies in governing emissions generated primarily in global ...
Jing Jin, Miaomiao Yin
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Biosecurity and globalising economic spaces [PDF]

Urbani Izziv, 2012
This chapter is concerned with the global regulation of animal health. Our case is a recent outbreak of avian influenza in South Africa’s ostrich industry. The analysis confirms an important theme in the emerging social sciences literature on biosecurity,
Charles Mather
doaj