Results 51 to 60 of about 241,695 (296)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The impact of regulatory frameworks on sustainable digital financial practices: Evidence from financial statement indicators in industrial firms

Heritage and Sustainable Development
This research explores how regulatory models contribute to sustainable digital financial transformation among industrial firms listed on global stock exchanges between 2015 and 2023.
Maytham Abed Kadhim, Bushra Hassan Mohamed El-Toby, Fadhil Hussein Abbas   +2 more
doaj   +1 more source

The Coproduction of the Global Regulatory Regime for Food Safety Standards and the Limits of a Technocratic Ethos [PDF]

SSRN Electronic Journal, 2014
Several socio-legal scholars have studied how the Codex Alimentarius Commission (Codex) was empowered by the World Trade Organization (WTO) and how, under this transition, its standards became quasi-binding. What has gone less studied is how the WTO has transformed the very modus operandi of Codex.
openaire   +3 more sources

The political economy of Hong Kong's "open skies" legal regime: an empirical and theoretical exploration [PDF]

, 2009
Copyright 2009 San Diego International Law Journal. Reprinted with the permission of the San Diego International Law Journal.The article presents an empirical and theoretical research which describes the functions of the international legal regime ...
Mushkat, M, Mushkat, R
core   +1 more source

Complex and unexpected dynamics in simple genetic regulatory networks [PDF]

, 2014
Peer reviewedPublisher ...
Afnan Alagha, Ahmed Alsaedi, Ajo-Franklin C. M., Alexey Zaikin, Anderson J. C., Andrianantoandro E., Atkinson M. R., Balazsi G., Balsalobre A., Bonnet J., Bratsun D., Cambras T., Carr A. F., Carr A. J., Cohen M., Danino T., Darren Nesbeth, Ekkehard Ullner, Eldar A., Elowitz M. B., Fernando C. T., Fraser A., Friedland A. E., Fung E., García-Ojalvo J., Gardner T. S., Glass L., Golomb D., Gonze D., Gonze D., Granados-Fuentes D., Granados-Fuentes D., Gurdon J. B., Han S. K., Hastings M. H., Hastings M. H., Herzog E. D., Hogenesch J. B., Hänggi P., Inagaki N., Khalil A. S., King D. P., Kiss I. Z., Ko C. H., Kobayashi H., Koseska A., Levskaya A., Levskaya A., Lewis J., Liu T., Lu T. K., Lutz R., Maywood E. S., McClung C. R., McMillen D., Meinhardt H., Moran L. A., Munsky B., Murray-Zmijewski F., Müller K., Nicolis G., Ohta H., Pokhilko A., Purcell O., Quintero J. E., Raser J. M., Ruder W. C., Siuti P., Stricker J., Swain P., Swain P., Tabor J. J., Tabor J. J., Tamsir A., Tigges M., Tigges M., Tiwari A. F., Ullner E., Ullner E., Volkov E. I., Wang W., Wang W., Weber W., Westermark P. O., Yamaguchi S., Yamazaki S., Yanika Borg, Ye H., You L.   +88 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Self-reference in International Law

Eunomia
Self-reference pervades international law. Treaty-based regimes –the most robust forms of international authority– typically coexist, exhibiting patterns of legal pluralism.
Pablo Zapatero
doaj   +1 more source

Regulatory Competition in Global Financial Markets — The Case for a Special Resolution Regime

Annals of Corporate Governance, 2016
Regulatory arbitrage in financial markets refers to a number of strategies that market participants use to avoid the reach of regulation, in particular by virtue of moving trading abroad or relocating activities or operations of financial institutions to other jurisdictions.
openaire   +1 more source

Technical Capacity, Policymaking and Food Standards: An Overview of Indian Experience [PDF]

, 2008
The SPS Agreement in the WTO gives legal validity to the CODEX\ud standards. Since the developed countries have been at the forefront of\ud setting the food standards in the CODEX, the developing countries have\ud been increasingly engaged in the CODEX ...
Chowdhury, Nupur, Kumar, Sanjay
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source