Results 81 to 90 of about 241,695 (296)

Algorithmic regulation and the global default: Shifting norms in Internet technology

Etikk i Praksis: Nordic Journal of Applied Ethics, 2016
The world we inhabit is surrounded by ‘coded objects’ from credit cards to airplanes to telephones (Kitchin and Dodge 2011).  Sadly the governance mechanisms of many of these technologies are only poorly understood, leading to the common premise that ...
Ben Wagner
doaj   +1 more source

Redefining the great powers: the revisionist model and the emergence of a global regulatory regime for cross-border tax intermediation

, 2022
The international tax system has been the locus of both international scandals and sweeping regulatory change since the Global Financial Crisis of 2008 (GFC). Starting with two highly publicised international tax scandals involving Switzerland’s UBS and Liechtenstein’s LGT banks, the past decade witnessed a string of further scandals including some of ...
openaire   +3 more sources

Common Capital: A Thought Experiment in Cross-Border Resolution [PDF]

, 2014
Cross-border bank resolution efforts focus on burden-sharing between bank owners, private creditors and the public. There is little talk of burden-sharing among governments, despite the rich history of governments trying to stick one another with the ...
Gelpern, Anna
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Compliance mechanisms of the draft global plastics treaty: theory, current status, and prospects

Frontiers in Marine Science
Marine plastic pollution, with its transboundary nature, persistence, and extensive harmful impacts, has become a pressing challenge to the ecological security and sustainable development of the global ocean.
Xiongbing Qiao
doaj   +1 more source

Considerations in relation to off-site emergency procedures and response for nuclear accidents [PDF]

, 2017
The operation of nuclear facilities has, fortunately, not led to many accidents with off-site consequences. However, it is well-recognised that should a large release of radioactivity occur, the effects in the surrounding area and population will be ...
Arnold, Ashley, Astbury, Aumonier, Bosley, British Energy Generation Ltd, British Energy Generation Ltd, Charnock, Clarke, Dohrenwend, Farmer, Fullwood, G.J. Vaughan, Gering, Grimston, Haywood, Heffron, Hicks, ICRP, ICRP, International Chernobyl Project, Johnson, Jones, Kaldor, Medvedev, Ministry for Economy, Trade and Industry, Nathwani, Nathwani, National Research Council, National Research Council, OECD, P.J. Thomas, Pasquill, Ranghieri, S.F. Ashley, Steinhauser, Thomas, Thomas, Thomas, Thomas, Thomas, Thomas, Thomas, Thomas, Thomas, Thomas, Thomas, Till, UNSCEAR, UNSCEAR, UNSCEAR, UNSCEAR,, W.J. Nuttall, Waddington, Waddington, Waddington, Wakeford, Yabe, Yasumura, Yumashev   +59 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Climate emergency impacts and adaptations in shipping: Analogical policy formulation and recommendations

Journal of International Maritime Safety, Environmental Affairs, and Shipping
The impacts of the climate emergency and the need to implement adaptation strategies in shipping have garnered growing attention due to the potential economic disruptions.
Lamin Jawara, Tafsir Matin Johansson
doaj   +1 more source

The Quest for International Rule of Law and the Rise of Global Regulatory Regimes Some Theoretical Preliminaries

SSRN Electronic Journal, 2015
This paper addresses the rise of global regulatory regimes within a broader theoretical framework of the international rule of law. Section 1 focuses on the question of who should be ultimate beneficiaries of the international rule of law, and it challenges Waldron’s claim that these should be individuals, rather than states.
openaire   +2 more sources