Results 61 to 70 of about 2,615,111 (244)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Results in EngineeringThis study investigates the local and global sensitivity of five critical durability parameters affecting concrete performance in chloride environments: concrete cover thickness (d), apparent chloride diffusion coefficient (Dₐₚₚ), surface chloride ...
Lingjie Wu +3 more
doaj +1 more source
Global Sensitivity Analysis of CASC2D Hydrological Model Parameters [PDF]
长江科学院院报[Objectives] The parameter calibration of the CASC2D hydrological model is mainly based on manual trial-and-error methods. It lacks a global sensitivity analysis of model parameters and the identification of relationships between parameters and ...
LI Xiao-ying, ZHANG Jin-hui, ZHAO Hong-jie
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Sensitivity analysis and parameter estimation for evaluating the impact of water pollution on aquatic species [PDF]
Computational Ecology and SoftwareAquatic ecosystems are highly sensitive to changes in environmental conditions, making it essential to identify the key factors that influence the dynamics of species populations.
Christopher David Ngalya +2 more
doaj
Coasting: Model description, global sensitivity analysis, and scenario discovery
MethodsX, 2020 This manuscript provides information for replicating the Coasting agent-based model presented in “Simulating emerging coastal tourism vulnerabilities: an agent-based modelling approach”.
Jillian Student +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Accelerated global sensitivity analysis of genome-wide constraint-based metabolic models
BMC Bioinformatics, 2021 Background Genome-wide reconstructions of metabolism opened the way to thorough investigations of cell metabolism for health care and industrial purposes.
Marco S. Nobile +3 more
doaj +1 more source