Results 61 to 70 of about 949,435 (263)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

GLOBAL EXPERIENCE OF TAX STIMULATION OF SOFTWARE DEVELOPMENT INDUSTRY

Вестник университета, 2017
The article presents arguments to stimulate innovation and software development and describes main types of tax incentives for innovation activity and software development abroad.
S. Kravchuk
doaj   +1 more source

Requirements Change Management Challenges of Global Software Development: An Empirical Investigation

IEEE Access, 2020
The software organizations rapidly adopting global software development (GSD) to gain the economic and strategic benefits. Besides, GSD faces many challenges that mainly concerned with the requirements change management (RCM). This study aims to identify
Muhammad Azeem Akbar, Wishal Naveed, Abeer Abdulaziz Alsanad, Lulwah Alsuwaidan, Ahmed Alsanad, Abdu Gumaei, Muhammad Shafiq, Muhammad Tanveer Riaz   +7 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Communication and personality profiles of global software developers [PDF]

Information and Software Technology, 2015
Context: Prior research has established that a small proportion of individuals dominate team communication during global software development. It is not known, however, how these members' contributions affect their teams' knowledge diffusion process, or whether their personality profiles are responsible for their dominant presence.
Sherlock A. Licorish, Stephen G. MacDonell   +1 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Degrees of tenant isolation for cloud-hosted software services: a cross-case analysis

Journal of Cloud Computing: Advances, Systems and Applications, 2018
A challenge, when implementing multi-tenancy in a cloud-hosted software service, is how to ensure that the performance and resource consumption of one tenant does not adversely affect other tenants.
Laud Charles Ochei, Julian M. Bass, Andrei Petrovski   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Identification and Prioritization of Cloud Based Global Software Development Best Practices

IEEE Access, 2020
The cloud based global software development (CGSD) is the most widely adopted development paradigm in software industry. The CGSD offers significant economic and strategic benefits; besides, various complexities are faced by the practitioners while ...
Muhammad Azeem Akbar, Sajjad Mahmood, Hussain Alsalman, Abdul Razzaq, Abdu Gumaei, Muhammad Tanveer Riaz   +5 more
doaj   +1 more source