Results 11 to 20 of about 3,181,687 (256)
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Gender and innovation processes in wheat-based systems [PDF]
, 2020 This WHEAT report is based on 43 village case studies from eight countries set in diverse wheat-based farming regions of the Global ...
Badstue, Lone B. +3 more
core
The agroecological transition of agricultural systems in the Global South [PDF]
, 2018 Food security, jobs, ecological transition of agricultural production models and consumption patterns... Agroecology could be one of the solutions to meet the future challenges of humanity. Part of the United Nation's 17 Sustainable Development Goals, it
Côte, François-Xavier (ed.) +5 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
If I Ruled the World: Putting Hip Hop on the Atlas [PDF]
, 2019 “If I Ruled the World: Putting Hip Hop on the Atlas” contends for a third wave of Global Hip Hop Studies that builds on the work of the first two waves, identifies Hip Hop as an African diasporic phenomenon, and aligns with Hip Hop where there are no ...
Harris, Travis T. +2 more
core +1 more source
Coffee, cash, and consumption: rethinking commodity production in the global south [PDF]
, 2018 This essay reflects on the study of coffee production in Angola, following research in business and missionary archives in the Netherlands and the United Kingdom. After observing that African coffee farmers were consumers of foreign goods as much as they
Vos, Jelmer
core +1 more source