Results 71 to 80 of about 538,934 (316)

Global stability of nonlinear feedback systemswith positive descriptor linear parts [PDF]

Bulletin of the Polish Academy of Sciences: Technical Sciences, 2019
The global (absolute) stability of nonlinear systems with negative feedbacks and positive descriptor linear parts is addressed. Transfer matrices of positive descriptor linear systems are analyzed.
T. Kaczorek
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Global stability of an age-structured epidemic model with general Lyapunov functional

Mathematical Biosciences and Engineering, 2019
In this paper, we focus on the study of the dynamics of a certain age structured epidemic model. Our aim is to investigate the proposed model, which is based on the classical SIR epidemic model, with a general class of nonlinear incidence rate with some ...
Abdennasser Chekroun, Mohammed Nor Frioui , Toshikazu Kuniya , Tarik Mohammed Touaoula   +3 more
doaj   +1 more source

Global Behavior of a Multi–Group Seir Epidemic Model with Spatial Diffusion in a Heterogeneous Environment

International Journal of Applied Mathematics and Computer Science, 2022
In this paper, we propose a multi-group SEIR epidemic model with spatial diffusion, where the model parameters are spatially heterogeneous. The positivity and ultimate boundedness of the solution, as well as the existence of a global attractor of the ...
Liu Pengyan, Li Hong-Xu
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Global dynamics of an age-structured malaria model with prevention

Mathematical Biosciences and Engineering, 2019
In this paper, we formulate a new age-structured malaria model, which incorporates the age of prevention period of susceptible people, the age of latent period of human and the age of latent period of female Anopheles mosquitoes.
Zhong-Kai Guo , Hai-Feng Huo, Hong Xiang
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Sensitivity analysis of a mathematical model for malaria transmission accounting for infected ignorant humans and relapse dynamics

Frontiers in Applied Mathematics and Statistics
This article presents and analyzes a deterministic model for malaria transmission that incorporates infected individuals who are unaware of their infectious status (ignorant infected humans) and accounts for relapse dynamics.
Getahun Tadesse Haile, Purnachandra Rao Koya, Fekadu Mosisa Legesse   +2 more
doaj   +1 more source