Results 11 to 20 of about 2,794 (216)

Evaluation of Global Climate and Storm-Resolving Model Representations of Mixed-Phase Clouds and Their Hemispheric Contrasts

Atmosphere
Mixed-phase clouds, in which liquid droplets and ice crystals coexist at temperatures between −38 °C and 0 °C, play a critical role in Earth’s radiation budget.
Olimpia Bruno, Jonah K. Shaw, Trude Storelvmo, Corinna Hoose   +3 more
doaj   +1 more source

How the representation of microphysical processes affects tropical condensate in the global storm-resolving model ICON [PDF]

Atmospheric Chemistry and Physics
Cloud microphysics is a prime example of processes that remain unresolved in atmospheric modeling at storm-resolving resolution. In this study, we explore how uncertainties in the representation of microphysical processes affect the tropical condensate ...
A. K. Naumann, A. K. Naumann, M. Esch, B. Stevens   +3 more
doaj   +1 more source

Contrasting Improvements in Storm‐Track Activity Over the North Atlantic and North Pacific in Global Storm‐Resolving Models: A Case Study in the Winter of 2020

Geophysical Research Letters
Storm‐resolving models have the potential to outperform conventional models with a horizontal resolution of 150 km in simulating global atmospheric circulation by resolving deep convection and gravity waves.
R. Masunaga, C. Kodama, S. Okajima, A. Yamazaki, T. Miyakawa   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Radiative, Hydrologic, and Circulation Responses to Warming in Cess‐Potter Simulations Using the Global 3.25‐km SCREAM

Journal of Advances in Modeling Earth Systems
Using the global 3.25‐km Simple Cloud Resolving E3SM Atmosphere Model (SCREAM 3 km), a pair of 13‐month Cess‐Potter simulations are performed to quantify the radiative feedbacks and the hydrologic and circulation responses to warming. Large‐scale aspects
C. R. Terai, N. D. Keen, P. M. Caldwell, H. Beydoun, P. A. Bogenschutz, L.‐W. Chao, B. R. Hillman, H.‐Y. Ma, M. D. Zelinka, L. Bertagna, A. M. Bradley, T. C. Clevenger, A. S. Donahue, J. Foucar, J.‐C. Golaz, O. Guba, W. Hannah, J. Lee, W. Lin, N. Mahfouz, J. Mülmenstädt, A. G. Salinger, B. Singh, S. Sreepathi, Y. Qin, M. A. Taylor, P. A. Ullrich, W.‐Y. Wu, X. Yuan, C. S. Zender, Y. Zhang   +30 more
doaj   +1 more source

Tropical Cirrus in Global Storm‐Resolving Models: 2. Cirrus Life Cycle and Top‐of‐Atmosphere Radiative Fluxes

Earth and Space Science, 2022
Cirrus clouds of various thicknesses and radiative characteristics extend over much of the tropics, especially around deep convection. They are difficult to observe due to their high altitude and sometimes small optical depths. They are also difficult to
S. M. Turbeville, J. M. Nugent, T. P. Ackerman, C. S. Bretherton, P. N. Blossey   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

On the Realism of Tropical Cyclone Intensification in Global Storm‐Resolving Climate Models

Geophysical Research Letters
The physical processes governing a tropical cyclone's lifecycle are largely understood, but key processes occur at scales below those resolved by global climate models. Increased resolution may help simulate realistic tropical cyclone intensification. We
Alexander J. Baker, Benoît Vannière, Pier Luigi Vidale   +2 more
doaj   +1 more source

Correcting Coarse‐Grid Weather and Climate Models by Machine Learning From Global Storm‐Resolving Simulations

Journal of Advances in Modeling Earth Systems, 2022
Global atmospheric “storm‐resolving” models with horizontal grid spacing of less than 5 km resolve deep cumulus convection and flow in complex terrain.
Christopher S. Bretherton, Brian Henn, Anna Kwa, Noah D. Brenowitz, Oliver Watt‐Meyer, Jeremy McGibbon, W. Andre Perkins, Spencer K. Clark, Lucas Harris   +8 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source