Results 71 to 80 of about 2,794 (216)

On–Off Switchable Micromotors for Use in Steerable Microvehicles

Advanced Robotics Research, EarlyView.
Electrically controllable micromotors and microvehicles are developed by tuning the diffusion of the fuel. Self‐propelled micromotors using bubble propulsion show great promise for miniaturized devices with multiuse purposes such as cargo delivery and sensing. However, there is currently no method to electrically switch the micromotors on or off. Here,
Hugo Severinsson, Eswaran Murugasen, Jose G. Martinez, Edwin W. H. Jager   +3 more
wiley   +1 more source

The Vertical Structure of Tropical Temperature Change in Global Storm‐Resolving Model Simulations of Climate Change

Geophysical Research Letters
Global storm‐resolving model (GSRM) simulations (kilometer‐scale horizontal resolution) of the atmosphere can capture the interaction between the scales of deep cumulus convection and the large‐scale dynamics and thermodynamic properties of the ...
Timothy M. Merlis, Ilai Guendelman, Kai‐Yuan Cheng, Lucas Harris, Yan‐Ting Chen, Christopher S. Bretherton, Maximilien Bolot, Linjiong Zhou, Alex Kaltenbaugh, Spencer K. Clark, Stephan Fueglistaler   +10 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Bridging the Gap Between Global Weather Prediction and Global Storm‐Resolving Simulation: Introducing the GFDL 6.5‐km SHiELD

Journal of Advances in Modeling Earth Systems
We introduce a 6.5‐km version of the Geophysical Fluid Dynamics Laboratory (GFDL)'s System for High‐resolution prediction on Earth‐to‐Local Domains (SHiELD).
Linjiong Zhou, Lucas Harris, Jan‐Huey Chen, Kun Gao, Kai‐Yuan Cheng, Mingjing Tong, Alex Kaltenbaugh, Matthew Morin, Joseph Mouallem, Lauren Chilutti, Lily Johnston   +10 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Constructing Worst-Scenario typhoon storm surge in a changing climate by 2040s: The typhoon Mangkhut (2018) simulations in Hong Kong

Weather and Climate Extremes
Hong Kong's extensive coastline and dense economic development render it highly vulnerable to tropical cyclone-induced storm surges, a risk exacerbated by projected global warming and rising sea levels over the 21st century.
Zhenning Li, Jimmy C.H. Fung, Alexis K.H. Lau, Chi Ming Shun, Jimmy W.M. Chan, Yue Zhang   +5 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

High Performance, High Fidelity: A GPU‐Accelerated Doubly‐Periodic Configuration of the Simple Cloud‐Resolving E3SM Atmosphere Model Version 1 (DP‐SCREAMv1)

Journal of Advances in Modeling Earth Systems
The development of the Simplified Cloud Resolving Energy Exascale Earth System Atmosphere Model (SCREAMv1) enables global storm‐resolving simulations on modern GPU‐based supercomputers.
P. A. Bogenschutz, T. C. Clevenger, A. M. Bradley, P. M. Caldwell, H. Beydoun, N. Mahfouz, N. D. Keen, O. Guba, L. Bertagna, J. Foucar, J. Zhang, A. S. Donahue   +11 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source