Results 61 to 70 of about 5,230,276 (287)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Higher structure of non-invertible symmetries from Lagrangian descriptions
Journal of High Energy PhysicsThe symmetry structure of a quantum field theory is determined not only by the topological defects that implement the symmetry and their fusion rules, but also by the topological networks they can form, which is referred to as the higher structure of the
Seolhwa Kim, Orr Sela, Zhengdi Sun
doaj +1 more source
Global Analysis by Hidden Symmetry [PDF]
, 2017 Special volume in honor of Roger Howe on the occasion of his 70th ...
openaire +2 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Global symmetry-breaking and generalized theta-terms in Type IIB EFTs
Journal of High Energy Physics, 2023 A longstanding conjecture states that global symmetries should be absent in quantum gravity. By investigating large classes of Type IIB four-dimensional N $$ \mathcal{N} $$ = 2 effective field theories, we enlist the potential generalized global ...
Thomas W. Grimm +2 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Dynamical versus variational symmetries: understanding Noether's first theorem [PDF]
, 2004 It is argued that awareness of the distinction between dynamical and variational symmetries is crucial to understanding the significance of Noether's 1918 work.
Holland, Peter, Brown, Harvey R.
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Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Global symmetries of noncommutative space-time [PDF]
Physical Review D, 2005 7 pages, no figures; minor changes in the bibliography; final version accepted for publication in Phys.
Gonera, C. +3 more
openaire +2 more sources
, 2007 While empirical symmetries relate situations, theoretical symmetries relate models of a theory we use to represent them. An empirical symmetry is perfect if and only if any two situations it relates share all intrinsic properties. Sometimes one can use a
Healey, Richard
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