Results 121 to 130 of about 1,744,467 (339)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Digital Infrastructure and Agricultural Global Value Chain Participation: Impacts on Export Value-Added

open access: yesAgriculture
[Objective] Digital infrastructure, with its fundamental and public good characteristics, can have a significant impact on export trade. This paper aims to analyze the impact and mechanism of digital infrastructure construction on the added value of ...
Yutian Zhang, Linyan Ma, Feng Wei
doaj   +1 more source

The Global Value Chain in Coronavirus Era: An Impact Approach [PDF]

open access: yesRomanian Economic Journal, 2020
Global Value Chains (GVC) play a particular role in the mechanisms of world economy and any disruption of them has strong unwanted consequences on their operation. Our research aims to identify and characterize the negative impact of COVID-19 on GVCs and,
Victor Danciu
doaj  

Does Trade Policy Impact Food and Agriculture Global Value Chain Participation of Sub‐Saharan African Countries?

open access: yesAmerican Journal of Agricultural Economics, 2018
&NA; The emergence of food and agriculture global value chains (GVCs) is challenging the way scholars look at trade data, as well as how policy makers establish their trade policies.
J. Balié   +4 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Factory Europe – changes in trade and GVC [PDF]

open access: yes, 2019
Artykuł został przygotowany na konferencję ETSG 2019 Conference in Bern, Universiy of Bern 12-14.09.2019. Po wprowadzeniu niewielkich zmian zostanie przygotowany do publikacji.Three main regions can be distinguished: Factory Asia, Factory Europe, and ...
Nacewska-Twardowska, Aleksandra
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Global Value Chains, Technology Transfer and Local Firm Upgrading in Non-OECD Countries [PDF]

open access: yes
The productivity and competitiveness of local firms in non-OECD countries depends as much on technological capacities and successful upgrading as in industrialized countries.
Juliane Brach, Robert Kappel
core  

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