Results 131 to 140 of about 1,744,467 (339)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Role of Inter-Organizational Leadership in Agri-Food Value Chains [PDF]

For many years research on marketing channel behaviour was focused on power and conflict between channel members. More recently, as a result of globalisation, firms have become more dependent on each other and more collaborative models of channel ...
Dooley, Lawrence B., Luca, E.
core   +1 more source

Poland's Participation in Global Value Chains [PDF]

, 2019
Artykuł został przygotowany na konferencję 6th Academy of International Business Central Eastern European (AIB-CEE) Chapter Annual Conference on „International Business in the Dynamic Environment: Changes in Digitalization, Innovation and ...
Nacewska-Twardowska, Aleksandra
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

How does environmental regulation reshape global value chain resilience?

Cleaner Environmental Systems
Escalating ecological challenges, such as global warming and environmental pollution, have made carbon emission control and enhanced environmental governance global priorities.
Ye Yang, Guiqin Xue
doaj   +1 more source

Technology capacity, product position and firm’s competitiveness: an empirical analysis [PDF]

Using firm-level data from a 2009 survey conducted in Suzhou City, Jiangsu Province, China, this paper examines impacts of technology capacity and value-chain position on firm’s product competitiveness.
Gao, Yanyan, Liu, Zhibiao, Song, Shunfeng, Zheng, Jianghuai   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Performance Improvements through Implementation of Lean Practices: A Study of the U.K. Red Meat Industry [PDF]

'Lean' is an established industrial paradigm with proven track record in various sectors of the industry (Womack & Jones, 1996). World-class Companies such as Toyota (second biggest global car manufacturer), Porsche (most profitable global OEM), Boeing ...
Simons, David, Zokaei, Keivan
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Environmental Upgrading and Suppliers’ Agency in the Leather Global Value Chain

, 2019
The paper explores the role of suppliers in the process of environmental upgrading (EnvU) within global value chains (GVCs). Theoretical contributions to EnvU have highlighted, in particular, the role of global buyers in supporting the EnvU of products ...
V. Marchi, E. Maria
semanticscholar   +1 more source