Results 61 to 70 of about 747,986 (295)

Knowledge, Oligopoly and Labour in Global Value Chains

Global Labour Journal, 2020
The article explores knowledge in global value chains (GVCs) and its correspondence with the nature of employment in different GVC segments. It starts with the role of knowledge that is protected through intellectual property rights in creating ...
Dev Nathan
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Poland's Participation in Global Value Chains [PDF]

, 2019
Artykuł został przygotowany na konferencję 6th Academy of International Business Central Eastern European (AIB-CEE) Chapter Annual Conference on „International Business in the Dynamic Environment: Changes in Digitalization, Innovation and ...
Nacewska-Twardowska, Aleksandra
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Global Restructuring of Value Chains and Class Issues

Revue Interventions Économiques, 2009
This paper looks at the impacts of the restructuring of global value chains on skills, occupational identities, class position and class consciousness. The codification of tacit knowledge and standardisation of work processes are both preconditions for ...
Ursula Huws, Simone Dahlmann
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Global Value Chains in Africa [PDF]

, 2015
This paper provides evidence on the extent of Global Value Chain (GVC) participation by Africa as a region and for individual African countries. We find that Africa as a whole is heavily involved in GVCs, being more engaged in GVCs than many developing ...
Foster-McGregor, Neil, Kaulich, Florian, Stehrer, Robert   +2 more
core   +1 more source

Tourism global value chains and Africa

, 2017
As Africa continues to attract record numbers of international arrivals, there are industry undercurrents that influence the continent's participation in tourism value chains.
Daly, Jack, Gereffi, Gary
core   +2 more sources