Results 131 to 140 of about 125,612 (305)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Is Social Europe Fit for Globalisation? A Study of the Social Impact of Globalisation in the European Union. CEPS Special Reports, March 2008 [PDF]
, 2008 Globalisation is one of the defining phenomena of today’s economy, albeit one that is loosely defined and prone to exaggeration. For many, globalisation is an opportunity, affording scope on the supply side for increased specialisation, enhanced ...
Mortensen, Jørgen +2 more
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How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
How Globalisation Shapes Public Policy? A Case of Azerbaijan [PDF]
Is globalisation a conductive or destructive force for public policy development in the countries of transition? The problem is investigated through an example of oil-rich Azerbaijan.
Gugushvili, Alexi
core
On globalisation and exceptionalism [PDF]
, 2011 The twin concepts of globalisation and exceptionalism appear antithetical. Globalisation implies degrees of convergence. Exceptionalism connotes difference and diversity.
Muncie, John, Muncie, J
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Packaging of organic food—the dilemma of consumers’ internal and external motives
Frontiers in SustainabilityThis study provides empirical insights to clarify consumers’ motives for choosing organic food and the importance of the packaging of organic food in shaping consumers’ perceptions of food organicity. Based on a survey of 497 consumers of organic food in
Olena Nifatova +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The Journal of Studies in Language, Culture and SocietyThis paper attempts to shed light on how women use figurative language through songs and dances in the Fe’efe’e traditional community to speak out their cries and yearnings.
Gabriel Delmon Djomeni
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source