Results 131 to 140 of about 77,983 (316)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Packaging of organic food—the dilemma of consumers’ internal and external motives
Frontiers in SustainabilityThis study provides empirical insights to clarify consumers’ motives for choosing organic food and the importance of the packaging of organic food in shaping consumers’ perceptions of food organicity. Based on a survey of 497 consumers of organic food in
Olena Nifatova +5 more
doaj +1 more source
, 2008 Globalisation is one of the defining phenomena of today’s economy, albeit one that is loosely defined and prone to exaggeration. For many, globalisation is an opportunity, affording scope on the supply side for increased specialisation, enhanced ...
Begg, Iain +2 more
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The Journal of Studies in Language, Culture and SocietyThis paper attempts to shed light on how women use figurative language through songs and dances in the Fe’efe’e traditional community to speak out their cries and yearnings.
Gabriel Delmon Djomeni
doaj
Ubiquity ProceedingsThis experience presents the design, implementation, and evaluation of an institutional AI Learning Tutor to support undergraduate students' learning within a flipped classroom approach in business school settings.
Irina Otmanine +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The impact of globalisation on Australian finance law and financial services law
, 2012 This thesis examines the impact of globalisation on areas of innovative legislative change, policy development and law reform in Australian finance law and financial services law.
Horgan, Sharon
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