Results 171 to 180 of about 125,612 (305)

Food packaging: identifying the socio-economic drivers and reduction opportunities through system dynamics modelling. [PDF]

Global Health
Chakori S, Aziz AA, Richards R.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Fast-moving consumer goods, slow-moving policy: structures and strategies of China's e-cigarette industry and global regulatory challenges. [PDF]

Tob Control
Xu SS, Quah ACK, Fong GT.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Impact of Globalisation and Economic Reforms on Employment in India [PDF]

In this paper, the basics of globalization, the economic reforms initiated in India and the trends in employment and the impact of globalisation are discussed. It is argued that the unorganised workers would expand further due to globalisation. Under the
Helen, Mary Jacqueline, Dhas, Albert Christopher   +1 more
core  

Global tastes, local choices: Strontium isotope and concentration evidence for changing dietary input in Roman Nijmegen, the Netherlands. [PDF]

PLoS One
De Coster M, Hendriks J, James HF, Snoeck C, Davies GR, Kootker LM.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Globalisation

, 2000
Summaries This article argues that the current phase of neoliberal globalisation presents a challenge to the prospects for equitable social development in developing and transition economies.
Bob Decon (19307332)
core  

Global health and the dialectics of solidarity through Ubuntu and European perspectives. [PDF]

BMJ Glob Health
Anyikwa CL.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source