Results 191 to 200 of about 292,771 (316)

A geography of indoors for analyzing global ways of living using computer vision. [PDF]

Sci Rep
Mazzarello M, Klimenka M, Sanatani R, Eshtiyagh J, Yao Y, Santi P, Duarte F, Florida R, Ratti C.   +8 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Starving for Data: Eating Disorders Prevalence and Research Gaps in Southern Africa. [PDF]

Int J Eat Disord
Melisse B, Bijsterbosch JM, Sternheim L.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Values and ethics for implementation fidelity and integrity of public health policy in a multipolar world with conflicting value systems. [PDF]

J Public Health (Oxf)
Mfutso Bengo J, Mfutso Bengo E.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Unpacking the influence of ICT on respiratory diseases in Sub-Saharan Africa. [PDF]

Sci Rep
Luo H, Zhang L, Sun Y, Zhang L.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

An Interdisciplinary Forum on Time and Globalization [PDF]

, 2021
Stockdale, Liam, O’Brien, Susie, Porter, Tony, Furlotte, Charles, Zhou, Rachel, Rethmann, Petra, Huebener, Paul, Breu, Christopher   +7 more
core  

When Standard Newborn Screening Isn't Enough: Diagnostic Challenges in the Age of Globalization. [PDF]

Clin Case Rep
Ortúzar Menéndez M, Mendiguren LM, Garde Garde MC, Pérez Ollo S, Campion Mezquiriz A, Moreno-Galarraga L.   +5 more
europepmc   +1 more source