Results 61 to 70 of about 53,195 (239)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

New Light on the Formation and Evolution of M31 and its Globular Cluster System

, 2005
We present spectroscopic ages, metallicities, and [alpha/Fe] ratios for 70 globular clusters in M31 that were derived from Lick line-index measurements.
Alongi, Aoki, Ashman, Baade, Barbuy, Barmby, Barmby, Barmby, Barmby, Beasley, Beasley, Bellazzini, Brodie, Brodie, Brown, Bruzual, Burstein, Burstein, Carretta, Carretta, Chaboyer, Chernoff, Christlieb, Christlieb, Cohen, Cohen, Cohen, Côté, Côté, Davidge, Davidge, Davidge, Djorgovski, Durrell, Durrell, Durrell, Edvardsson, Esteban, Ferguson, Ferraro, Font, Forbes, Forbes, Fryer, Fuhrmann, Galleti, Greggio, Harris, Heger, Hempel, Holland, Huchra, Ibata, Ibata, Jiang, Jogee, Jordán, K. M. Perrett, King, Kundu, Kuntschner, Kuntschner, Larsen, Larsen, Larsen, Li, Li, Mackey, Maeder, Maraston, Matteucci, Matteucci, McConnachie, McConnachie, Morgan, Morrison, Norris, Norris, Norris, O'Connell, Olsen, Origlia, Origlia, Peebles, Perrett, Perrett, Pettini, Ponder, Puzia, Puzia, Puzia, Puzia, Rauch, Rich, Salaris, Sarajedini, Schroder, Schwarzkopf, Schwarzkopf, Searle, Spinrad, Sánchez-Blázquez, T. H. Puzia, T. J. Bridges, Thomas, Thomas, Tomkin, Trager, Trager, Tripicco, Tripicco, Tsujimoto, van den Bergh, van den Bergh, van den Bergh, van den Hoek, Vazdekis, Velazquez, Widrow, Woosley, Worthey, Worthey, Worthey, Zibetti   +123 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Extrapolating SMBH correlations down the mass scale: the case for IMBHs in globular clusters

, 2009
Empirical evidence for both stellar mass black holes M_bh10^5 M_sun) is well established. Moreover, every galaxy with a bulge appears to host a SMBH, whose mass is correlated with the bulge mass, and even more strongly with the central stellar velocity ...
A. Wandel, A.A. Kiselev, A.D. Mackey, A.J. Barth, A.J. Barth, B. Lanzoni, B.M. Peterson, B.M.S. Hansen, C. Pryor, C.T. Berghea, D. Chen, D. Merritt, D.E. McLaughlin, D.E. McLaughlin, E. Noyola, E.H. Wehner, E.J.M. Colbert, F.N. Bash, G. Marchi De, G.A. Drukier, G.A. Drukier, G.E. Brown, G.E. Schwarz, G.L. Granato, H. Akaike, H. Baumgardt, H. Baumgardt, J. Gerssen, J. Gerssen, J. Hu, J. Kormendy, J. Kormendy, J. Magorrian, J. Miralda-Escudé, J. Yoo, J.E. Greene, J.E. Greene, J.E. Greene, J.M. Bromley, J.N. Bahcall, J.R. Hurley, J.S.B. Wyithe, K. Gebhardt, K. Gebhardt, K. Gebhardt, K. Gültekin, K. Mužić, L. Ferrarese, L. Ferrarese, L. Origlia, M. Colpi, M. Favata, M. Gill, M. Pasquato, M. Valluri, M. Volonteri, M.C. Begelman, M.C. Bentz, M.C. Miller, M.G. Haehnelt, Margarita Safonova, N. Kawakatu, P. Barmby, P. Dubath, P. Miocchi, P.M. Lugger, Prajval Shastri, R Project software, R. Ibata, R.P. Marel van der, R.P. Marel van der, S. Bergh van den, S. Bergh van den, S. Rijcke de, S. Tremaine, S.C. Trager, S.F. Portegies Zwart, S.L. Shapiro, T. Boeker, T.J. Maccarone, T.R. Lauer, W.E. Harris, W.H. Press, X. Dong   +83 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Gravitational Microlensing by Globular Clusters [PDF]

, 1998
Stars in globular clusters can act either as sources for MACHOs (Massive Astrophysical Compact Halo Objects) located along the line of sight or as lenses for more distant background stars.
Jetzer, P., Strässle, M., Wandeler, U.
core   +1 more source

The Globular Cluster System of M31 [PDF]

Symposium - International Astronomical Union, 2002
This review presents the current status of our knowledge of M31 star clusters. Given the broadness of the subject, I chose to focus on some of its aspects which are not covered by the other participants in this conference.
openaire   +2 more sources