Results 91 to 100 of about 89,654 (284)
Enrichment by supernovae in globular clusters with multiple populations
, 2009 The most massive globular cluster in the Milky Way, omega Centauri, is thought to be the remaining core of a disrupted dwarf galaxy, as expected within the model of hierarchical merging.
Kang, Young-Woon +3 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The Astrophysical Journal, 1992 This is a paper from 1992 distributed on arXiv with permission from AAS.
openaire +2 more sources
Globular Clusters and Galaxy Formation [PDF]
, 2008 8 pages, 6 figures, Globular Clusters - Guides to Galaxies ...
openaire +3 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The Astrophysical JournalGlobular clusters contain vast repositories of metal-poor stars that represent some of the oldest stellar generations in the Universe. The archaeological footprint of early Galactic evolution may be retained in the measurable properties of globular ...
Roman Gerasimov +6 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
The Astrophysical Journal LettersA meta-analysis of seismic ages determined for individual stars in the well-studied open and globular clusters NGC 6819, NGC 6791, M67, M4, M19, M80, and M9 reveals both high variance across measurements and a possible discrepancy with independent ...
Jamie Tayar, Meridith Joyce
doaj +1 more source