Results 101 to 110 of about 89,654 (284)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
JWST NIRCam Observations of the Globular Cluster Population of RXJ 2129.7+0005
The Astrophysical JournalWe present an analysis of the globular cluster (GC) population in the galaxy cluster RXJ 2129.7+0005 ( z = 0.234) based on JWST NIRCam imaging in three filters: F115W, F150W, and F200W.
Kaitlyn E. Keatley, William E. Harris
doaj +1 more source
Gravitational Microlensing by Globular Clusters [PDF]
, 1998 Stars in globular clusters can act either as sources for MACHOs (Massive Astrophysical Compact Halo Objects) located along the line of sight or as lenses for more distant background stars.
Jetzer, P., Strässle, M., Wandeler, U.
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Metallicities of Globular Clusters m3 and m5 from VI CCD Photometry [PDF]
Journal of Astronomy and Space Sciences, 2000 To derive the metallicities of M3 and M5, we used the shape of red giant branch, horizontal branch magnitude, and red giant branch bump on the (V - I) - V color magnitude diagrams.
Young-Jong Sohn, Hyun-Chul Lee
doaj +2 more sources
Rotation and Hα Emission in a Young SMC Cluster: A Spectroscopic View of NGC 330
The Astrophysical JournalWe present an analysis of high-resolution optical spectra recorded for 30 stars of the split extended main-sequence turnoff of the young (∼40 Myr) Small Magellanic Cloud globular cluster NGC 330.
Paul I. Cristofari +6 more
doaj +1 more source
Nature, 1888 PHYSICAL aggregations of stars may be broadly divided into “globular” and “irregular” clusters. Although, as might have been expected, the line of demarcation between the two classes is by no means sharply drawn, each has its own marked peculiarities. We shall limit our attention, in the present article, to the first kind.
openaire +1 more source