Results 51 to 60 of about 89,654 (284)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Prospects for Detecting Fast Radio Bursts in the Globular Clusters of Nearby Galaxies
The Astrophysical Journal, 2023 The recent detection of a repeating fast radio burst (FRB) in an old globular cluster in M81 challenges traditional FRB formation mechanisms based on the magnetic activity of young neutron stars formed in core-collapse supernovae.
Kyle Kremer +4 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Evidence for an accretion origin for the outer halo globular cluster system of M31
, 2010 We use a sample of newly-discovered globular clusters from the Pan-Andromeda Archaeological Survey (PAndAS) in combination with previously-catalogued objects to map the spatial distribution of globular clusters in the M31 halo. At projected radii beyond ~
Bellazzini +23 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
THE FLATTENING OF GLOBULAR CLUSTERS [PDF]
The Astronomical Journal, 1983 In the three nearest luminous galaxies, the Milky Way System, the Andromeda Galaxy and NGC 5128 the brightest globular clusters are rounder than the faintest ones. On the other hand (contrary to some previous results) the flattening of individual LMC clusters is found to be independent of their luminosities.
openaire +3 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
The Astrophysical JournalThe LIGO/Virgo/Kagra (LVK) Collaboration has detected numerous binary black hole (BBH) mergers with properties that challenge standard binary evolution scenarios, such as component masses above the pair-instability gap and high spin magnitudes.
Aidan Mai, Kyle Kremer, Fulya Kıroğlu
doaj +1 more source
Metallicity of Globular Cluster NGC 5053 from VI CCD Photometry [PDF]
Journal of Astronomy and Space Sciences, 2001 Red giant branch shape and the luminosity of horizontal branch on the (V-I)-V CMD are used to derive the metallcity of the globular cluster NGC 5053. The metallicities of NGC 5053 derived by SMR method ([Fe/H]=-2.62+-0.07) and the relation between [Fe/H]
Young-Jong Sohn
doaj