Results 81 to 90 of about 89,654 (284)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

NUMERICAL MODELING OF GLOBULAR CLUSTERS TIDAL DISSOLUTION

Odessa Astronomical Publications, 2013
Numerical model of dynamical evolution of globular clusters(GCs) is described, with an emphasis of the mass loss rate in tidal interactions with the Galaxy.
M. V. Ryabova, F. G. Sendzikas, Yu. A. Shchekinov   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Globular clusters in ORBIT: Complete dynamical characterisation of the Milky Way globular cluster population through updated orbital reconstruction

Astronomy & Astrophysics
Context. In hierarchical structure formation, the content of a galaxy is determined both by its in-situ processes and by material added via accretions.
De Leo M., Zoccali M., Olivares-Carvajal J., Acosta-Tripailao B., Gran F., Contreras-Ramos R.   +5 more
doaj   +1 more source

Multivariate analysis of the globular clusters in M87

, 2015
An objective classification of 147 globular clusters in the inner region of the giant elliptical galaxy M87 is carried out with the help of two methods of multivariate analysis.
Chattopadhyay, Tanuka, Das, Sukanta, Davoust, Emmanuel   +2 more
core   +1 more source

Globular Clusters in Nearby Galaxy Clusters [PDF]

, 2006
6 pages, 4 figures, to appear in Proceedings of the ESO Workshop on "Extragalactic Globular Cluster Systems", ed. M. Kissler-Patig, Springer Verlag (2002)
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Production Rate of SN Ia Events in Globular Clusters

, 2012
In globular clusters, dynamical evolution produces luminous X-ray emitting binaries at a rate about 200 times greater than in the field. If globular clusters also produce SNe Ia at a high rate, it would account for much of the SN Ia events in early type ...
Angelini, Artyukhina, Binney, Dimai, Evans, Evans, Gebhardt, Giordano, Goudfrooij, Harris, Heinke, Irwin, Itagaki, Itagaki, Jacques, Joel N. Bregman, Jordán, Kissler-Patig, Kissler-Patig, Kosai, Kundu, Kundu, Kundu, Kundu, Liller, Mandushev, Mazza, Meikle, Modjaz, Moore, Nakano, Pearce C. Washabaugh, Pfahl, Pooley, Pooley, Puckett, Quimby, Riess, Riess, Sarazin, Shara, Sivakoff, Suzuki, Tsvetkov, Washabaugh   +44 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source