Results 191 to 200 of about 85,801 (378)

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han   +9 more
wiley   +1 more source

Spectral Energy Distribution Fitting of Globular Clusters in NGC 4874: Masses and Metallicities

open access: yesThe Astrophysical Journal
In most nearby galaxies, photometry of the integrated light of their globular clusters (GCs) has been obtained in only two filters, yielding just a single color index.
Kate Hartman   +2 more
doaj   +1 more source

Variable stars in the VVV globular clusters

open access: yesAstronomy & Astrophysics
Context. High reddening near the Galactic plane hampers observations and proper characterization of the globular clusters (GCs) located toward the inner regions of the Milky Way. Aims. The VISTA Variables in the Vía Láctea (VVV) survey observed the Galactic bulge and adjacent disk for several years, providing multi-epoch, near-infrared images for 41 ...
Javier Alonso-García   +15 more
openaire   +2 more sources

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini   +7 more
wiley   +1 more source

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich   +10 more
wiley   +1 more source

Intense Star Cluster Formation: Stellar Masses, the Mass Function, and the Fundamental Mass Scale

open access: yesThe Astrophysical Journal Letters
Within the birth environment of a massive globular cluster, the combination of a luminous young stellar population and a high column density induces a state in which the thermal optical depth and radiation pressure are both appreciable.
Christopher D. Matzner
doaj   +1 more source

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