Results 161 to 170 of about 691,066 (375)

Influence of Expansion of Extracellular Volume on Tubular Reabsorption of Sodium Independent of Changes in Glomerular Filtration Rate and Aldosterone Activity * [PDF]

, 1964
Floyd C. Rector, George Van Giesen, Fredrik Kiil, Donald W. Seldin   +3 more
openalex   +1 more source

Pharmacokinetics and pharmacodynamics of empagliflozin in paediatric patients aged 10–17 years with type 2 diabetes mellitus

British Journal of Clinical Pharmacology, EarlyView.
Aims To characterize the pharmacokinetics (PK) and PK/pharmacodynamics (PD) regarding glycosylated haemoglobin (HbA1c) lowering using the paediatric data from DINAMO and to assess differences compared with adults. Methods Population PK and PK/PD models previously developed for empagliflozin in adults and adolescents were re‐estimated in a Bayesian ...
Juliane Rascher, Shen Cheng, Curtis Johnston, Sebastian Härtter, Wojtyniak Jan‐Georg, Jan Marquard, Igor Tartakovsky, Lori M. B. Laffel   +7 more
wiley   +1 more source

Effective plasma volume in cirrhosis with ascites. Evidence that a decreased value does not account for renal sodium retention, a spontaneous reduction in glomerular filtration rate (GFR), and a fall in GFR during drug-induced diuresis [PDF]

, 1969
Fred L. Lieberman, Sosuke Ito, Telfer B. Reynolds   +2 more
openalex   +1 more source

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza, Michaela Semeraro, Gabrielle Lui, Léo Froelicher‐Bournaud, Laure Choupeaux, Jean‐Marc Treluyer, Sihem Benaboud, Joelle Terzic, Eric Hachulla, Philippe Remy, Jérôme Harambat, Alexandre Karras, Caroline Rousset‐Rouviere, Anne Jolivot, Zahir Amoura, Eric Daugas, Aurélie Hummel, Rémi Salomon, Jean‐Christophe Lega, Stéphane Decramer, Alexandre Belot, Delphine Gobert, Nathalie Costedoat‐Chalumeau, Stanislas Faguer, Isabelle Melki, Noémie Jourde‐Chiche, Brigitte Bader‐Meunier   +26 more
wiley   +1 more source

Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes

Cells
Accumulating evidence indicates that inflammatory and immunologic processes play a significant role in the development and progression of glomerular diseases.
Wadih Issa, Rachel Njeim, Arianna Carrazco, George W. Burke, Alla Mitrofanova   +4 more
doaj   +1 more source

Evidence That an Acute Increase in Glomerular Filtration Has Little Effect on Sodium Excretion in the Dog unless Extracellular Volume is Expanded* [PDF]

, 1967
Marshall D. Lindheimer, Richard C. Lalone, Norman G. Levinsky   +2 more
openalex   +1 more source

Population pharmacokinetics and optimized dosing of cefuroxime in critically ill patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cefuroxime is a second‐generation cephalosporin widely used in the intensive care unit (ICU). ICU patients have high variability in interpatient pharmacokinetics (PK), but the extent of this variation is unclear. We performed an observational PK study in ICU patients.
Jaap W. A. Mouton, Julian D. Machiels, Arthur M. A. Pistorius, Rob ter Heine, Tim Frenzel, Nynke G. L. Jager, Jeroen A. Schouten, Paddy K. C. Janssen, Rob E. Aarnoutse, Roger J. Brüggemann   +9 more
wiley   +1 more source

Renal Blood Flow, Glomerular Filtration Rate, Renal PAH Extraction Ratio, and the Role of the Renal Vasomotor Nerves in the Unanesthetized Rabbit [PDF]

, 1963
PAUL I. Pascoe, Yvonne Körner
openalex   +1 more source

Probability of pharmacokinetic/pharmacodynamic target attainment for different piperacillin/tazobactam dosing regimens in renally impaired patients in a non‐intensive care unit setting

British Journal of Clinical Pharmacology, EarlyView.
Aims To optimize antibiotic therapy for pathogens classified as susceptible, increased exposure (I), an increased exposure of piperacillin/tazobactam (PTZ) is required. However, dosing recommendations are currently only available for patients with normal renal function.
Emma Dohmann, Stefan Hagel, Max Kurlbaum, Paul Schellong, Oliver Scherf‐Clavel, Güzin Surat   +5 more
wiley   +1 more source

Renal blood‐flow and glomerular filtration

, 1922
E. B. Mayrs, J. M. Watt
openalex   +2 more sources