Results 221 to 230 of about 691,066 (375)

Comparison of Regression and Categorical Analysis for Pharmacokinetic Data From Renal Impairment Studies

Clinical Pharmacology &Therapeutics, EarlyView.
The US Food and Drug Administration 2024 guidance prefers regression analysis over categorical analysis for pharmacokinetic data for studies that assess pharmacokinetics in patients with impaired renal functions. The objective of this study was to compare these two statistical methods for pharmacokinetic data analysis of renal impairment studies ...
Gerald Chun‐To So, Ying Grace Li, Stephen D. Hall, Jenny Chien, Christopher D. Payne, Maria M. Posada, Maria Lucia Buziqui Piruzeli, Yan Jin   +7 more
wiley   +1 more source

Individualized calibration of estimated glomerular filtration rate for serial renal function determination: a pilot study. [PDF]

Sci Rep
Mekonnen BW, Holness JL, Berndorfler BD, Lombard C, Warwick JM.   +4 more
europepmc   +1 more source

Administration Studies in Equine Antidoping Research: Designing Scientific Investigations to Effectively Direct Medication Control in Racehorses

Drug Testing and Analysis, EarlyView.
ABSTRACT Pharmacokinetics is the study of the movement of drug in the body and includes the processes of absorption, distribution, metabolism, and excretion. Pharmacodynamics is the pharmacologic effect of the drug on the body. The pharmacokinetics of a drug determines its pharmacologic effect. Pharmacokinetic studies describe drug concentrations while
Heather K. Knych
wiley   +1 more source

The Impact of Living Kidney Donor Glomerular Filtration Rate on Graft Survival. [PDF]

Medicina (Kaunas)
Cakmak U, Merhametsiz O, Ay N.
europepmc   +1 more source

Influence of glomerular filtration rate on the rate of para-aminohippurate secretion by the rat kidney: Micropuncture and clearance studies

, 1975
Dieter A. Häberle, Angelika Ober, G. Ruhland   +2 more
openalex   +1 more source

Renal function during acute and long term pindolol treatment in hypertensive patients with normal and decreased glomerular filtration. [PDF]

, 1982
J Rosenfeld, Geoffrey Boner, E Wainer
openalex   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

A neural network approach to glomerular filtration rate estimation: a single-centre retrospective audit. [PDF]

Nucl Med Commun
Johnson JA, Meades R, Dickinson NJ.
europepmc   +1 more source

Measurement of glomerular filtration rate utilizing a single subcutaneous injection of 125I-iothalamate

, 1973
Arnold H. Israelit, Dewey L. Long, Martin White, Alan R. Hull   +3 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source