Results 71 to 80 of about 691,066 (375)

Gla-rich protein (GRP) as an early and novel marker of vascular calcification and kidney dysfunction in diabetic patients with CKD: a pilot cross-sectional study [PDF]

, 2020
Vascular calcification (VC) is one of the strongest predictors of cardiovascular risk in chronic kidney disease (CKD) patients. New diagnostic/prognostic tools are required for early detection of VC allowing interventional strategies.
Almeida, Edgar de, Dias, Carolina, Faísca, Marília, Guilherme, Patrícia, Macedo, Ana, Mendes, Filipa, Neves, Pedro Leão, Rato, Fátima, Santos, Nélio, Silva, Ana P., Simes, Dina, Tavares, Nelson, Viegas, Carla   +12 more
core   +1 more source

Measurement and Estimation of Glomerular Filtration Rate in Children.

Advances in Chronic Kidney Disease, 2017
Rapid, accurate, and precise measures of kidney function are essential for daily management of patients. While plasma and urinary clearances provide the greatest accuracy for assessing glomerular filtration rate (GFR), these are often impractical ...
Ayesa N. Mian, G. Schwartz
semanticscholar   +1 more source

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

Advanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang   +13 more
wiley   +1 more source

Proenkephalin, neutrophil gelatinase-associated lipocalin, and estimated glomerular filtration rates in patients with sepsis [PDF]

, 2017
Background: Proenkephalin (PENK) has been suggested as a novel biomarker for kidney function. We investigated the diagnostic and prognostic utility of plasma PENK in comparison with neutrophil gelatinase-associated lipocalin (NGAL) and estimated ...
Andreas Bergmann, Hanah Kim, Joachim Struck, Laura Magrini, Mina Hur, null null, Oliver Hartmann, Patrizia Cardelli, Rossella Marino, Salvatore Di Somma, Seungho Lee   +10 more
core   +1 more source

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

Correlation of total cholesterol and protein in urine in patients with the nephrotic syndrome [PDF]

, 1980
The excretion of protein and cholesterol in 24 h urine was measured in 42 patients with the nephrotic syndrome.
Jüngst, Dieter, Karl, Hans Josef, Wallner, J.   +2 more
core   +1 more source

Biofabrication of a Filtration Barrier by Integrating Electrospun Membranes and Flow in a Glomerular Co‐Culture

Advanced Healthcare Materials, EarlyView.
An ex vivo glomerular filtration barrier is engineered using electrospun, biomimetic membranes seeded with human glomerular cells. The model supports fenestrated endothelium and podocyte foot processes under flow, mimics size‐selective filtration, and enables disease modeling with hiPSC‐derived podocytes, offering a powerful platform for studying ...
Camilla Mussoni, Anna Rederer, Vladimir Stepanenko, Frank Würthner, Philipp Stahlhut, Jürgen Groll, Mario Schiffer, Taufiq Ahmad, Janina Müller‐Deile   +8 more
wiley   +1 more source

Capillary‐Driven 3D Open Fluidic Networks for Versatile Continuous Flow Manipulation

Advanced Materials, EarlyView.
The capillary‐driven 3D open fluidic networks (OFNs), composed of connected polyhedral frames, enable precise, programmable, and versatile manipulation of unary, binary, and multiple continuous flows in both spatial and temporal dimensions. OFNs represent a significant leap beyond conventional microfluidics, unlocking new possibilities for selective ...
Shuangmei Wu, Siqi Sun, Jia Ye, Liqiu Wang, Yiyuan Zhang   +4 more
wiley   +1 more source

Association between urinary sodium, creatinine, albumin, and long term survival in chronic kidney disease [PDF]

, 2014
Dietary sodium intake is associated with hypertension and cardiovascular risk in the general population. In patients with chronic kidney disease, sodium intake has been associated with progressive renal disease, but not independently of proteinuria.
Fox, Jonathan G., Freel, E. Marie, Jardine, Alan G., Mark, Patrick, McQuarrie, Emily P., Taylor, Alison H., Traynor, Jamie P.   +6 more
core   +1 more source

A High‐Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury

Advanced Materials Technologies, EarlyView.
Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar, Anushree Chakravarty, Kimia Asadi Jozani, Brenda Truong, Matana Hendrickson, Ahmed Attia, Muna Sabouny, Anna Basatskaya, Sergi Clotet‐Freixas, Madeleine Ludlow, Alexander Sotra, Dawn S. Y. Lin, Feng Zhang, Boyang Zhang   +13 more
wiley   +1 more source