Results 201 to 210 of about 319,649 (342)

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Acute fall in glomerular filtration rate with renin–angiotensin system inhibition: a biomeasure of therapeutic success? [PDF]

, 2011
Matthew R. Weir
openalex   +1 more source

Changes in uric acid levels and estimated glomerular filtration rate slope after treatment with dotinurad in patients with hyperuricemia. [PDF]

BMC Nephrol
Mizoguchi T, Hayashi K, Tsuruta Y, Kawada Y, Yokoi M, Yamabe S, Mori K, Matsui K, Ito T, Kitada S, Goto T, Seo Y.   +11 more
europepmc   +1 more source

Safety, Pharmacokinetics, and Dose Recommendations for Nirmatrelvir/Ritonavir in Individuals with Mild to Moderate COVID‐19 and Severe Renal Impairment

Clinical Pharmacology &Therapeutics, EarlyView.
Patients with severe renal impairment and COVID‐19 are at high risk for severe disease and death. Nirmatrelvir/ritonavir, an antiviral therapy for COVID‐19, is eliminated by renal excretion and can accumulate in patients with severe renal impairment.
Jacqueline Gerhart, Candace R. Bramson, Michelle Goulding, Haihong Shi, Olayide Oladoyinbo, Phylinda L. S. Chan, Sunring Chime, Jennifer Hammond   +7 more
wiley   +1 more source

Estimating Glomerular Filtration Rate in Young Persons With Obesity or Diabetes and Hyperfiltration. [PDF]

Kidney Int Rep
Bekelman NJ, Pyle L, Choi YJ, Hampson HE, Narongkiatikhun P, Pinzón Cortés JA, Tommerdahl KL, Bjornstad P.   +7 more
europepmc   +1 more source

Safety, Tolerability, and Pharmacokinetics of GMDTC for Cadmium Poisoning: A Randomized Phase 1a/1b Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Cadmium exposure causes serious health consequences; however, there is no clinically approved antidote for cadmium poisoning. This Phase 1a/1b trial aimed to investigate safety, tolerability, and pharmacokinetics of Sodium (S)‐2‐(dithiocarboxylato((2S,3R,4R,5R)‐2,3,4,5,6‐pentahydroxyhexyl) amino)‐4‐(methylthio) butanoate (GMDTC), a novel chelating ...
Xuefeng Ren, Wei Hu, Xiaobin Deng, Rong Ma, Fang Pei, Xushen Chen, Xuemei Wang, Jixin Tang, Yan Lai, Shangming Pan, Zhiyong Zhong, Sheng Fu, Huamin Yuan, Juan Yuan, Chuntao Huang, Yuan Zeng, Xiaodong Ying, Guanghui Dong, Jinxin Zhang, Jinyuan Zhao, Kangguang Lin, Xiaojiang Tang   +21 more
wiley   +1 more source

Prediction of Acute Glomerular Filtration Rate Reductions Following Renin-angiotensin System Blockade in Chronic Kidney Disease: A Possible Application of Ultrasonography in Clinical Practice

, 2019
Toshihiro Sugiura, Fuyuko Akagaki, Yoshito Yamaguchi, Aya Nakamori   +3 more
openalex   +2 more sources

Which glomerular filtration rate estimation equations should be used in youth with type 1 diabetes? [PDF]

Pediatr Nephrol
Kumar RS, Dalton RN, Marcovecchio ML.
europepmc   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Prognostic Value of Blood Pressure Rhythmicity for Estimated Glomerular Filtration Rate in Male Hypertensive Patients Aged 55 and Older [PDF]

Lulu Wang, Han Tian, X C Xu, Xinyan Gu, Qi Li, Hui Zheng, Jie Xu, Chunsun Dai, Lei Jiang   +8 more
openalex   +1 more source