Results 41 to 50 of about 112,911 (278)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Auxin-sensitive Aux/IAA proteins mediate drought tolerance in Arabidopsis by regulating glucosinolate levels. [PDF]

open access: yes, 2019
A detailed understanding of abiotic stress tolerance in plants is essential to provide food security in the face of increasingly harsh climatic conditions. Glucosinolates (GLSs) are secondary metabolites found in the Brassicaceae that protect plants from
Ecker, Joseph R   +7 more
core  

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

open access: yesArthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall   +9 more
wiley   +1 more source

Review of Thin Lithium Metal Battery Anode Fabrication – Microstructure – Electrochemistry Relations

open access: yesAdvanced Materials, EarlyView.
Thin, lightweight lithium‐metal anodes are pivotal for practical high‐energy batteries. This review surveys processing routes that convert diverse Li precursors, e.g., ingots, melts, solutions, and vapor, into Li‐rich foils with controlled thickness, areal density, and tailored functionality.
Yuhang Hu   +6 more
wiley   +1 more source

Grammar Learning Strategies and Language Attainment: Seeking a Relationship [PDF]

open access: yes, 2009
Despite major advances in research on language learning strategies, there are still areas that have received only scant attention, and one of them is undoubtedly learning grammar.
Pawlak, Mirosław
core   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

open access: yesAdvanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao   +6 more
wiley   +1 more source

GERAKAN LITERASI SEKOLAH DAN UPAYA MENINGKATKAN KEMAMPUAN MEMBACA PESERTA DIDIK DI MI SAMBINAE KOTA BIMA

open access: yesFashluna
Madrasah is a very good and strategic place to create a quality generation under the expectations of education and learning goals/, but to support this, the important role of all components and various elements is needed to work together to improve the ...
Trimansyah Trimansyah
doaj   +1 more source

Sulfur but not nitrogen supply increases the ITC/Nitrile ratio in Pak Choi (Brassica rapa subsp. chinensis (L.) Hanelt)

open access: yesJournal of Applied Botany and Food Quality, 2020
Glucosinolates (GLS) are a serendipitous class of secondary metabolites found in pak choi, a Chinese cabbage (Brassica rapa subsp. chinensis (L.) Hanelt).
Caroline A.C. Meschede   +2 more
doaj   +1 more source

qRgls1.06, a major QTL conferring resistance to gray leaf spot disease in maize

open access: yesCrop Journal, 2021
Gray leaf spot (GLS) caused by Cercospora zeae-maydis and C. zeina is an extremely devastating leaf disease that limits maize production annually. The use of GLS-resistant maize hybrids is the most cost-effective approach for reducing losses.
Hao Sun   +4 more
doaj   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

open access: yesAdvanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia   +6 more
wiley   +1 more source

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