Results 21 to 30 of about 34,139,948 (244)

A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes

Nature Communications, 2022
Glucagon-like peptide-1 receptor (GLP1R) agonists are used to treat type 2 diabetes (T2D), and polyagonists targeting multiple hormone receptors are investigated as potential therapeutics for T2D.
Hongwei Jiang, Shuguang Pang, Yawei Zhang, Ting Yu, Meng Liu, Huan Deng, Li Li, Liqi Feng, Baili Song, Han Han-Zhang, Qingyang Ma, Lei Qian, Wenying Yang   +12 more
doaj   +1 more source

Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation

Neural Regeneration Research, 2020
Glucagon-like peptide-1 receptor has anti-apoptotic, anti-inflammatory, and neuroprotective effects. It is now recognized that the occurrence and development of chronic pain are strongly associated with anti-inflammatory responses; however, it is not ...
Shan-Shan Cui, Xiao-Bo Feng, Bing-Hong Zhang, Zhong-Yuan Xia, Li-Ying Zhan   +4 more
doaj   +1 more source

Glucagon-like peptide-1 receptor imaging for localization of insulinomas [PDF]

, 2009
The surgical removal of insulinomas is hampered by difficulties to localize it using conventional radiological procedures. Recently these tumors were shown to exhibit a very high density of glucagon-like peptide-1 receptors (GLP-1R) in vitro that may be ...
Clerici, Thomas, Forrer, Flavio, Gloor, Beat, Reubi, Jean Claude, Rahel Sahli, Mäcke, Helmut R., Brändle, Michael, Beat Gloor, Martius, Ferdinand, Damian Wild, Reubi, Jean-Claude, Thomas Clerici, Flavio Forrer, Maecke, Helmut, Wild, Damian, Emanuel Christ, Ferdinand Martius, Christ, Emanuel, Sahli, Rahel, Jean Claude Reubi, Michael Brändle, Helmut Maecke   +21 more
core   +3 more sources

Dual Glucose-Dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Receptor Agonists

Endocrinology Research and Practice, 2022
Glucagon-like peptide-1 is the most potent incretin secreted from the intestinal tract. It is synthesized by L-cells in the jejunum and distal ileum of the gastrointestinal system.
Dilek Tüzün
doaj  

Glucagon-Like Peptide-1 Receptor Agonist Switching and Treatment Persistence in Adults Without Diabetes.

JAMA Netw Open
This cohort study evaluates glucagon-like peptide-1 (GLP-1) receptor agonist switching patterns and 12-month adherence and persistence among adults with overweight or obesity without ...
Xie L, Anazco D, Chancay AH, Mathew MS, Francis JM, Almandoz JP, Messiah SE.   +6 more
europepmc   +2 more sources

Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion [PDF]

, 2010
Context: Glucagon-like peptide-1 (GLP-1) is produced by specialized cells in the gut and secreted in response to carbohydrates and lipids. The mechanisms regulating fat-stimulated GLP-1 release have, however, not been clarified in detail.
Schirra, Joerg, D'Amato, Massimo, Göke, Burkhard, Drewe, Juergen, Beglinger, Svetlana, Beglinger, Christoph   +5 more
core   +1 more source

Glucagon-like peptide analogues for type 2 diabetes mellitus : systematic review and meta-analysis [PDF]

, 2010
Background Glucagon-like peptide (GLP-1) analogues are a new class of drugs used in the treatment of type 2 diabetes. They are given by injection, and regulate glucose levels by stimulating glucose-dependent insulin secretion and biosynthesis ...
Deepson S Shyangdan, Christine Clar, Pawana Sharma, Royle, Pamela L, Sharma Pawana, Royle Pamela L, Clar, Christine, Clar, C., Waugh, Norman R, Waugh Norman R, Pamela L Royle, Shyangdan Deepson S, Clar Christine, Waugh, Norman, Norman R Waugh, Sharma, Pawana, Shyangdan, D. (Deepson), Shyangdan, Deepson S, Royle, Pamela   +18 more
core   +2 more sources

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies [PDF]

, 2012
Modelling class B G-protein-coupled receptors (GPCRs) using class A GPCR structural templates is difficult due to lack of homology. The plant GPCR, GCR1, has homology to both class A and class B GPCRs. We have used this to generate a
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Barwell, James, Upton, Graham J.G., Poyner, David R., Reeves, Philip J., Upton, Graham J. G., Taddese, Bruck, Reeves, Philip J, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Conner, Alex C, Vohra, Shabana, Upton, Graham JG   +16 more
core   +1 more source

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Poyner, David, Reynolds, Christopher A., Hay, Debbie L., Poyner, David R, Karakullukcu, Z. Gamze, Woolley, Michael J, Barwell, James, Karakullukcu, Z Gamze, Poyner, David R., Smith, Kevin J., Taddese, Bruck, Reynolds, Christopher A, Conner, Alex C., Hay, Debbie L, Watkins, Harriet A., Watkins, Harriet A, Conner, Alex C, Smith, Kevin J, Woolley, Michael J.   +18 more
core   +1 more source

Glucagon-like peptide-1 receptor agonist versus basal insulin in type-2 diabetic patients: An efficacy and safety analysis [PDF]

, 2020
Purpose: To compare the effectiveness of glucagon-like peptide 1 receptor agonist with that of basal insulin in type 2 diabetes patients. Methods: Type-2 diabetes patients who were insensitive to metformin were treated with glucagon-like peptide 1 ...
Chen, Xiaxia, Lv, Qi, Lin, Kaiping, Lin, Ting, Yang, Xiaoling, Feng, Min   +5 more
core   +1 more source