Results 261 to 270 of about 137,002 (346)

Safety, feasibility, and dose‐dependent metabolic effects of endoscopic duodenal pulsed electric field therapy in adults with type 2 diabetes: Results from two multicentre proof‐of‐concept studies

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims The duodenum plays a central role in metabolic regulation, influencing insulin sensitivity, and glucose homeostasis. In type 2 diabetes (T2D), structural and functional abnormalities of the duodenal mucosa (“diabetic duodenopathy”) are increasingly recognized as contributors to insulin resistance and dysglycaemia.
David N. O'Neal, Adrian Sartoretto, Bronte A. Holt, Barham K. Abu Dayyeh, Rhys Vaughan, Georgina Cameron, Sujievvan Chandran, Alexander J. Thompson, Howard McCollister, Paul Severson, Andrew C. Storm, Lian Cunningham, Elif I. Ekinci   +12 more
wiley   +1 more source

Glucagon-Like Peptide-1 Receptor Agonists in Neurodegenerative Diseases: A Comprehensive Review. [PDF]

Cureus
Ibrahim R, Kambal A, Abdelmajeed MA.
europepmc   +1 more source

Effects of coaching with data management system intervention or usual care on glycemic control in patients with type 2 diabetes: A multicentre, randomised controlled trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Integrating a diabetes management system (DMS) and personal coaching in patient care may reduce the burden of type 2 diabetes (T2DM) on patients and help address the multifaceted challenges associated with diabetes management. This study aims to assess the impact of the DMS with online coaching in patients with T2DM on changes in HbA1c ...
Marlo Verket, Larissa F. Buitkamp, Niveditha Daneeza Dinesh Kanna, Andreas Thomas, Ralf Denger, Friedrich Petry, Oliver Schubert‐Olesen, Wolfgang Stütz, Jörg Simon, Monika Pihusch, Iris Dötsch, Gabriela Krob, Dietrich Tews, David Stolz, Dominik Bergis, Thorsten Lenthe, Frank Schmidt‐Mergenthaler, Elke Dahlmann, Kathrin Boehm, Malte Jacobsen, Dirk Müller‐Wieland, Julia Brandts   +21 more
wiley   +1 more source

Unintentional periconceptional exposure to glucagon-like peptide-1 receptor agonists and adverse pregnancy outcomes: A nationwide cohort study in Taiwan. [PDF]

Diabetes Obes Metab
Chou YC, Weng SH, Cheng FS, Tseng CH, Hu HY, Liu CH.   +5 more
europepmc   +1 more source

Providing holistic care for patients with metabolic dysfunction‐associated steatotic liver disease/metabolic dysfunction‐associated steatohepatitis: Key aspects of clinical assessment and how to develop individualised care plans for surveillance and interventions

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD), characterised by hepatic steatosis and metabolic dysfunction (i.e., obesity, type 2 diabetes, dyslipidaemia, and hypertension), is affecting over 30% of the adult population worldwide.
Lanlan Chen, Paul Horn, Frank Tacke
wiley   +1 more source

Glucagon-like peptide-1 receptor agonists in neuropathic pain: hype or hope? [PDF]

Korean J Pain
Choi JI.
europepmc   +1 more source

Real‐world effectiveness and safety of tirzepatide in Japanese patients with type 2 diabetes: A multi‐site retrospective study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Despite the established efficacy of tirzepatide in randomised controlled trials, real‐world effectiveness data in Japanese patients remain limited. This study evaluated the real‐world effectiveness and safety of tirzepatide in Japanese patients with type 2 diabetes over 52 weeks.
Yusuke Minakata, Masaki Miura, Nobuhiro Nakatake, Masahiro Masuzawa   +3 more
wiley   +1 more source

Efficacy and safety of glucagon-like peptide-1 receptor agonists in Parkinson's disease: a systematic review and meta-analysis of randomized placebo-controlled clinical trials. [PDF]

Ther Adv Neurol Disord
Stefanou MI, Panagiotopoulos E, Tentolouris A, Theodorou A, Papagiannopoulou G, Athanasaki A, Tsalouchidou PE, Peppa M, Lambadiari V, Konitsiotis S, Mengel A, Paraskevas GP, Tentolouris N, Tsivgoulis G.   +13 more
europepmc   +1 more source

Seizure recurrence after GLP‐1 receptor agonist initiation in adults with epilepsy

Epilepsia, EarlyView.
Abstract Objective To examine whether initiation of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) is associated with seizure recurrence and related outcomes in adults with epilepsy and type 2 diabetes. Methods We conducted a retrospective cohort study using de‐identified electronic health records from the TriNetX Research Network (January 2003 ...
Majd A. AbuAlrob, Abdullah Hussein, Rand Abdellatif, Adham Itbaisha, Khaled Zammar, Boulenouar Mesraoua   +5 more
wiley   +1 more source

Artificial lipidation of proteins and peptides: from mechanism to clinical applications

The FEBS Journal, EarlyView.
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley   +1 more source