Results 41 to 50 of about 913 (199)

Skeletal Muscle Microbiopsies in Children and Adults—Tolerability, Sample Yield, and Analyzability

open access: yesMuscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Traditional methods of sampling skeletal muscle tissue are invasive. This study aimed to evaluate a sub‐millimeter core‐biopsy (microbiopsy) as a potentially more tolerable method, with further regard to tissue yield and analyzability of RNA expression.
Emil Rydell Högelin   +9 more
wiley   +1 more source

Pseudorandomised controlled trial of a novel navel barrier solution versus 10% iodine to protect navel and ear tag sites of neonatal lambs

open access: yesVeterinary Record, EarlyView.
Abstract Background During lambing, 10% iodine is often used to protect neonatal navel and ear tag sites. The evidence for its effectiveness is sparse. Recently, a specific navel barrier solution (NBS) was developed. Here, an in vivo field trial compared the two treatments. Methods Ten farms reported data from 6840 lambs. The navel and ear tag sites of
Fiona M. Lovatt   +3 more
wiley   +1 more source

The Influence of Extracellular Citrate in Physiological Concentration on the Proliferation of Malignant Melanoma. [PDF]

open access: yesJ Cell Mol Med
ABSTRACT Cancer cells rely on citrate for multiple metabolic processes, suggesting that limiting the availability of extracellular citrate may represent a novel therapeutic strategy. The plasma membrane citrate transporter (pmCiC) has been implicated in the pathogenesis of several cancers before, and its activity can be inhibited by gluconate.
Drexler K   +8 more
europepmc   +2 more sources

Candidozyma cisalpinoae sp. nov., a Genomically Distinct, Flower‐Associated Yeast, Resistant to Azoles and Exhibiting Pathogenicity‐Related Traits

open access: yesYeast, EarlyView.
Candidozyma cisalpinoae sp. nov. represents a distinct species within the Candidozyma clade, supported by multilocus phylogeny, genome‐scale metrics, and phenotypic traits. Although isolated from floral substrates, this species displays several traits commonly associated with opportunistic pathogenic yeasts.
Anna Paula O. Tironi   +12 more
wiley   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

open access: yesIntegrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source

A remotely operated blood sampling and sedative administration device in freely moving pinnipeds

open access: yesMethods in Ecology and Evolution, EarlyView.
Abstract A remotely operated device for use with freely moving pinnipeds was designed and successfully developed for the collection of blood samples and the administration of sedatives via an indwelling, venous catheter. The performance of the sampler, called the ‘Mossquito’, was demonstrated on six wild caught, young‐of‐the‐year grey seals ...
Joanna L. Kershaw   +10 more
wiley   +1 more source

Enterococcus faecalis and Endodontic Treatment Failure: A Qualitative Systematic Review of Its Role and Elimination Strategies

open access: yesAustralian Endodontic Journal, EarlyView.
ABSTRACT The aim of this study was to synthesize evidence on the influence of Enterococcus faecalis on endodontic treatment failure and strategies for its elimination. This study followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and was registered in PROSPERO (CRD420251022741).
Francine Santos Fernandes de Lima   +1 more
wiley   +1 more source

Optimizing Prolonged (6 h) Normothermic Machine Perfusion of Donor Kidneys (PROPER Study)

open access: yesArtificial Organs, EarlyView.
Prolonged ex situ normothermic machine perfusion of donor kidneys up to 6 h is feasible, maintaining viability and histological integrity. Key protocol optimizations include fresh red blood cells, albumin supplementation, and urine recirculation—laying the groundwork for assessment and potential pretransplant interventions in future clinical trials ...
Asel S. Arykbaeva   +14 more
wiley   +1 more source

When Technology Falters: Ensuring Donor Safety and System Reliability Amid Apheresis Technical Challenges

open access: yesArtificial Organs, EarlyView.
This study reviews three adverse events during single donor platelet collection using root cause analysis. Causes included human error, equipment defects, and procedural lapses. Though all donors fully recovered, the incidents underscore the need for strict SOP adherence, staff training, and donor safety to maintain trust and donation retention.
Bhagyashri Surve   +4 more
wiley   +1 more source

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu   +4 more
wiley   +1 more source

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