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Glucose-6-phosphate dehydrogenase deficiency
Best Practice & Research Clinical Haematology, 2000Glucose-6-phosphate dehydrogenase (G6PD) is expressed in all tissues, where it catalyses the first step in the pentose phosphate pathway. G6PD deficiency is prevalent throughout tropical and subtropical regions of the world because of the protection it affords during malaria infection.
A, Mehta, P J, Mason, T J, Vulliamy
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Glucose-6-phosphate dehydrogenase deficiency
The Lancet, 2008Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, being present in more than 400 million people worldwide. The global distribution of this disorder is remarkably similar to that of malaria, lending support to the so-called malaria protection hypothesis.
M.D. Cappellini, G. Fiorelli
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Muscle glucose-6-phosphate dehydrogenase deficiency
Journal of Neurology, 1989Muscle glucose-6-phosphate dehydrogenase (G6PD) deficiency is described in four clinically heterogeneous patients: an athlete who developed myoglobinuria after physical exercise; a 7-year-old, mildly mentally retarded boy, who had episodes of dark urine and high creatine kinase; and two brothers of Sardinian origin, the elder showing moderate exercise ...
N, Bresolin +9 more
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Glucose-6-phosphate dehydrogenase deficiency
Baillière's Clinical Haematology, 1992Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzymopathy. Because its gene locus is on the X-chromosome it is more common in males than females in all populations. Prevalence rates vary from 62% among Kurdish Jews to the very low rates (0.1% or less in Japan, for example), which are compatible with sporadic cases arising
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Glucose 6-Phosphate Dehydrogenase Deficiency
2021Pentose phosphate pathway is sole source of NADPH in mammalian system. Glucose 6-phosphate dehydrogenase (G6PD) is one of the most important enzymes of this pathway. NADPH is utilized to reduce glutathione which is oxidized by free radicals in the human erythrocytes. It has been reported that deficiency or reduced activity of G6PD enzyme causes lack of
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Glucose 6-Phosphate Dehydrogenase (G6PD) Deficiency
2001Deficiency of the enzyme glucose 6-phosphate dehydrogenase (G6PD) in red blood cells is an inherited abnormality due to mutations of the G6PD gene on the X chromosome that renders the cells vulnerable to oxidative damage.
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Glucose-6-Phosphate Dehydrogenase Deficiency
Research Journal of Pharmacy and Technology, 2015Aim: To review the inheritance, manifestation and management of glucose-6-phosphate dehydrogenase deficiency Objective: The article reviews the inheritance, management and manifestation of glucose-6- phosphate dehydrogenase (G6PD) deficiency. Background: Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an X-linked recessive genetic ...
J. Insira Sarbeen, Gowri Sethu
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Cataracts in glucose-6-phosphate dehydrogenase deficiency
Ophthalmic Paediatrics and Genetics, 1993Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency plays an important biochemical role in the metabolism of the lens. Controversies exist in the literature on the possible association between G-6-PD deficiency and the development of cataracts. The authors present ten patients, aged between infancy and 40 years of age, who were admitted for bilateral
A A, Assaf, K F, Tabbara, M A, el-Hazmi
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Glucose‐6‐Phosphate Dehydrogenase Deficiency and Myelofibrosis
Scandinavian Journal of Haematology, 1973A presentation is made of a patient with myelofibrosis and chronic haemolytic anaemia. Known causes of haemolysis in combination with myelofibrosis were excluded. A hereditary red cell glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficiency was found. The case history is reported, along with the results of haematological investigations in the affected ...
O, Selroos, P, Vuopio
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Favism and Glucose-6-Phosphate Dehydrogenase Deficiency
New England Journal of Medicine, 2018Favism and Glucose-6-Phosphate Dehydrogenase Deficiency When persons with G6PD deficiency eat fava beans, acute hemolytic anemia may develop. It is caused by the generation of free radicals from the metabolism of glucosides in the beans. The free radicals damage red cells, resulting in intravascular and extravascular lysis.
Michael, Steiner +2 more
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