Results 61 to 70 of about 103,990 (298)

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

An In Situ Embedded B‐MOF Sponge With Shape‐Memory for All‐in‐One Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
A smart shape‐memory sponge dressing (P1A3@B‐MOF) is developed for accelerated diabetic wound healing. It achieves pH‐responsive corelease of Zn2+ and salvianolic acid B, synergistically providing antibacterial action, repolarizing macrophages to the M2 phenotype, and promoting angiogenesis.
Hai Zhou, Chaoyang Huang, Yanqi Chen, Tingzi Zhao, Fengyi Zhu, Gong Jun, Jinrong Zhang, Yingsong Pan, Qiulan Wen, Lei Yang, Huihui Zhang, Lianglong Chen   +11 more
wiley   +1 more source

Glucose-6-Phosphate Dehydrogenase Deficiency [PDF]

, 2020
Abstract Deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD) in red blood cells is an inherited abnormality due to mutations of the G6PD gene on the X chromosome that renders the cells vulnerable to oxidative damage. The condition is widespread in many populations living in or originating from tropical and subtropical ...
openaire   +2 more sources

Glucose - 6 - phosphate dehydrogenase deficiency In a group of Iraqi children

مجلة كلية الطب, 2005
Background: Glucose -6- phosphate deosphate dehydnogenase (G6PD) deficiency is a common problem in Iraqi as well as in tropical A subtropical region. Aim of study: to study the epidemiological aspect of G6PD deftaiency among Iraqi children.
Sawsan S. Abbas
doaj   +1 more source

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway. [PDF]

, 2014
The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide and amino acid biosynthesis, to provide reducing molecules for anabolism ...
Breitenbach, Michael, Brindle, Kevin M, Campbell, Kate, Cheung, Eric, Cramer, Thorsten, Grüning, Nana-Maria, Keller, Markus A, Krüger, Antje, Olin-Sandoval, Viridiana, Prigione, Alessandro, Rabinowitz, Joshua D, Ralser, Markus, Stincone, Anna, Tauqeer Alam, Mohammad, Wamelink, Mirjam MC   +14 more
core   +5 more sources

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

Treatment of pediatric burn patient having glucose-6-phosphate dehydrogenase deficiency

Indian Journal of Burns, 2016
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common red cell enzymopathy found in humans. It clearly has an X-linked recessive inheritance with its prevalence varying from 0% to 27% in a different caste, ethnic, and linguistic groups ...
Vijay Y Bhatia, Sankit D Shah, Harshil Y Ravalji, Deepa Banker   +3 more
doaj   +1 more source

Glucose-6-Phosphate Dehydrogenase Deficiency, Chlorproguanil-Dapsone with Artesunate and Post-treatment Haemolysis in African children treated for uncomplicated Malaria [PDF]

, 2012
Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA)
A Alloueche, A Jalloh, AB Tiono, Adoke Yeka, Ambrose Talisuna, Annie Robert, Atwine Daniel, B Bardsley, C De Araujo, C Ruwende, Carine Van Malderen, Carolyn Nabasumba, Chantal Van Overmeir, CI Fanello, CI Fanello, CV Plowe, DG Wootton, E Beutler, E Beutler, E Beutler, E Ochong, Eleanor Turyakira, F Nieuwenhuis, FP Mockenhaupt, Harry Van Loen, Jean-Pierre Van Geertruyden, MA Saunders, MD Cappellini, MZ Carrazza, Pascale Forret, Patrice Piola, PE Meissner, PJ Mason, Quique Bassat, R Kotea, Raquel González, S Krudsood, S Looareesuwan, S Parikh, Sonia Machevo, T Mutabingwa, The Four Artemisinin-Based Combinations (4ABC) group, Umberto D’ Alessandro, World Health Organization, World Health Organization, Z Premji   +45 more
core   +3 more sources

Microenvironment Modulation‐Based Nanomaterial‐Loaded Hydrogel Dressings for Diabetic Foot Ulcers: Research Progress and Future Perspectives

Advanced Materials Interfaces, EarlyView.
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing, Chen Hong, Fan Weijing, Huang Renyan, You Yang, Liu Guobin   +5 more
wiley   +1 more source

Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion [PDF]

, 2001
A female infant of nonconsanguineous Indian parents presented at 4 months with a hypoglycemic convulsion. Further episodes of hypoketotic hypoglycemia were associated with inappropriately elevated plasma insulin concentrations.
Aynsley-Green, A, Berger, R, Clayton, PT, Datta, V, Eaton, S, Edginton, M, Hussain, K, Krywawych, S, Malingre, HEM, van den Berg, IET   +9 more
core