Results 61 to 70 of about 679,700 (302)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Diboronic-Acid-Based Electrochemical Sensor for Enzyme-Free Selective and Sensitive Glucose Detection

Biosensors, 2023
A diboronic acid anthracene-based fluorescent system for detecting blood glucose could be used for 180 days. However, there has not yet been a boronic acid immobilized electrode to selectively detect glucose in a signal-increased way.
Joong-Hyun Kim, Hongsik Choi, Chul-Soon Park, Heung-Seop Yim, Dongguk Kim, Sungmin Lee, Yeonkeong Lee   +6 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Accuracy of a CGM Sensor in Pediatric Subjects With Type 1 Diabetes. Comparison of Three Insertion Sites: Arm, Abdomen, and Gluteus [PDF]

, 2017
Patients with diabetes, especially pediatric ones, sometimes use continuous glucose monitoring (CGM) sensor in different positions from the approved ones. Here we compare the accuracy of Dexcom\uae G5 CGM sensor in three different sites: abdomen, gluteus
Claudio Cobelli, Daniela Bruttomesso, Dario Iafusco, Ivana Rabbone, Marco Marigliano, null null, Riccardo Bonfanti, Riccardo Schiaffini, Roberto Visentin, Simone Del Favero, Simone Faccioli   +10 more
core   +2 more sources

Home blood glucose monitoring [PDF]

Diabetologia, 1979
Doctors find it impossible to stabilize and monitor diabetic patients in hospital without measuring blood glucose levels and it seemed logical that patients would also manage themselves better if they were able to measure blood glucose during their ordinary life.
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Continuous monitoring of blood glucose in the practice of endocrinologist

Ожирение и метаболизм, 2012
Continuous glucose monitoring - an important diagnostic, teaching and treatment tool for patients with diabetes mellitus, which is increasingly becoming a part of routine clinical practice in endocrinology.

doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Deep Learning‐Coupled Metabolic Heat Integrated Sensing System for Noninvasive Continuous Monitoring of Blood Glucose

Advanced Intelligent Systems
The dynamic and continuous monitoring of blood glucose (BG) concentration is crucial for the health management of diabetic patients. Despite its importance, significant challenges remain in the development of effective BG monitoring technologies ...
Haolin Wang, Chuanjie Yao, Zhibo Liu, Xinze Wang, Zhengjie Liu, Tao Zhang, Xinshuo Huang, LinGe Wang, Yuedan Wang, Gemin Xiao, Shady Farah, Hui‐jiuan Chen, Xi Xie   +12 more
doaj   +1 more source

High-Performance Bioinstrumentation for Real-Time Neuroelectrochemical Traumatic Brain Injury Monitoring [PDF]

, 2016
Traumatic brain injury (TBI) has been identified as an important cause of death and severe disability in all age groups and particularly in children and young adults.
Boutelle, M, Drakakis, EM, Gowers, S, Leong, C, Papadimitriou, K, Rogers, M, Wang, C   +6 more
core   +2 more sources