Results 101 to 110 of about 275,720 (332)

Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. [PDF]

, 2017
In the human sodium glucose cotransporter (hSGLT1) cycle, the protein undergoes conformational changes where the sugar-binding site alternatively faces the external and internal surfaces.
Gorraitz, Edurne, Hirayama, Bruce A, Loo, Donald DF, Paz, Aviv, Wright, Ernest M   +4 more
core   +2 more sources

Cellular and molecular cues of glucose sensing in the rat olfactory bulb

Frontiers in Neuroscience, 2014
In the brain, glucose homeostasis of extracellular fluid is crucial to the point that systems specifically dedicated to glucose sensing are found in areas involved in energy regulation and feeding behavior.
Dolly eAl Koborssy, Dolly eAl Koborssy, Brigitte ePalouzier-Paulignan, Rita eSalem, Marc eThevenet, Caroline eRomestaing, A. Karyn eJulliard   +6 more
doaj   +1 more source

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Paroxysmal eye–head movements in Glut1 deficiency syndrome [PDF]

, 2017
Objective:To describe a characteristic paroxysmal eye–head movement disorder that occurs in infants with Glut1 deficiency syndrome (Glut1 DS).Methods:We retrospectively reviewed the medical charts of 101 patients with Glut1 DS to obtain clinical data ...
De Vivo, Darryl C, Engelstad, Kristin, Goldberg, Michael E, Kane, Steven A, Pearson, Toni S, Pons, Roser   +5 more
core   +2 more sources

Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations

Biomedicines
Background: The anterior cingulate cortex (ACC) is known for its involvement in various regulatory functions, including in the central control of feeding.
Edina Hormay, Bettina László, István Szabó, Kitti Mintál, Beáta Berta, Tamás Ollmann, László Péczely, Bernadett Nagy, Attila Tóth, Kristóf László, László Lénárd, Zoltán Karádi   +11 more
doaj   +1 more source

Preclinical type 1 diabetes mellitus: a case from practice

Лечащий Врач, 2021
At the preclinical stage diabetes mellitus can be diagnosed based on laboratory studies of blood glucose and detection of autoantibodies to insulin (IAA), islet cells (ICA), glutamate decarboxylase (GADA), tyrosine phosphatase (IA2A) and zinc transporter
Yu. G. Samoilova, T. A. Filippova, M. V. Koshmeleva, O. A. Oleynik, E. V. Gorbatenko   +4 more
doaj  

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Comparison of sodium-glucose co-transporter-2 inhibitors and glucagon-like peptide-1 receptor agonists in myocardial infarction patients with type 2 diabetes [PDF]

, 2023
Jonathan Tjerkaski, Peter Ueda, Joakim Alfredsson, David Erlinge, Bertil Lindahl, Moman A. Mohammad, Elmir Ömerovic, Christian Reitan, Per Svensson, Tomas Jernberg   +9 more
openalex   +1 more source