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Milder phenotypes of glucose transporter type 1 deficiency syndrome [PDF]

Developmental Medicine & Child Neurology, 2011
Glucose transporter type 1 deficiency syndrome (GLUT1DS) is a treatable condition resulting from impaired glucose transport into the brain. The classical presentation is with infantile-onset epilepsy and severe developmental delay. Non-classical phenotypes with movement disorders and early-onset absence epilepsy are increasingly recognized and the ...
Anand, G., Padeniya, A., Hanrahan, D., Scheffer, H., Zaiwalla, Z., Cox, D., Mann, N., Hewertson, J., Price, S., Nemeth, A., Arsov, T., Scheffer, I., Jayawant, S., Pike, M., McShane, T.   +14 more
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Criss-cross gait [PDF]

Neurology, 2020
Nearly 90% of patients with glucose transporter type 1 deficiency syndrome (Glut1 DS; figure) have paroxysmal or constant gait abnormalities, including ataxic, spastic, ataxic-spastic, and dystonic gait.1,2 We report 3 cases of genetically proven Glut1 DS (table) demonstrating a distinctive paroxysmal gait disorder triggered by exertion or fasting ...
Francesca Magrinelli, Francesca Magrinelli, Kailash P. Bhatia, Anita Hennig, Eoin Mulroy, Giulia Di Lazzaro, Stephanie Grunewald, Anna Latorre, Susanne A. Schneider, Darryl C. De Vivo   +9 more
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The Efficacy and Safety of the Combination Therapy With GLP-1 Receptor Agonists and SGLT-2 Inhibitors in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis

Frontiers in Pharmacology, 2022
Aims: Glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors play a key role in the treatment of type 2 diabetes mellitus.
Chen Li, Chen Li, Jie Luo, Jie Luo, Mingyan Jiang, Mingyan Jiang, Keke Wang, Keke Wang   +7 more
doaj   +1 more source

Effect of duodenal-jejunal bypass on diabetes in the early postoperative period

Scientific Reports, 2023
Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period.
Shohei Okikawa, Hideya Kashihara, Mitsuo Shimada, Kozo Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Yuma Wada, Toshiaki Yoshimoto   +8 more
doaj   +1 more source

Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Perturbations in myocardial substrate utilization have been proposed to contribute to the pathogenesis of cardiac dysfunction in diabetic subjects.
Manoja K. Brahma, Chae‐Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende   +10 more
doaj   +1 more source

Translocation of the brain-type glucose transporter largely accounts for insulin stimulation of glucose transport in BC3H-1 myocytes [PDF]

Biochemical Journal, 1990
Insulin-stimulated glucose transport was examined in BC3H-1 myocytes. Insulin treatment lead to a 2.7 +/- 0.3-fold increase in the rate of deoxyglucose transport and, under the same conditions, a 2.1 +/- 0.1-fold increase in the amount of the brain-type glucose transporter (GLUT 1) at the cell surface.
D M Calderhead, Gwyn W. Gould, Gustav E. Lienhard, K Kitagawa   +3 more
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An Unusual Presentation of Glucose Transporter Type 1 Deficiency Syndrome [PDF]

Journal of Health and Allied Sciences NU, 2018
AbstractGlucose serves as the major energy sources for developing brain. In the resting state, the adult brain can consume up to 25% of the body's total glucose supply, while in infants and children it can use as much as 80%. Glucose entry into brain occurs via glucose transporter proteins GLUTs). They are five GLUTs protein.
G Saritha, S Bhavani
openaire   +1 more source

Exercise training-induced PPARβ increases PGC-1α protein stability and improves insulin-induced glucose uptake in rodent muscles [PDF]

, 2020
This study aimed to investigate the long-term effects of training intervention and resting on protein expression and stability of peroxisome proliferator-activated receptor β/δ (PPARβ), peroxisome proliferator-activated receptor gamma coactivator 1-α ...
Holloszy, John O, Kim, Kijin, Koh, Jin-Ho, Park, Ju-Sik   +3 more
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A Different SLC2A1 Gene Mutation in Glut 1 Deficiency Syndrome: c.734A>C

Balkan Medical Journal, 2017
Background: Glucose transporter type 1 deficiency syndrome is the result of impaired glucose transport into the brain. Patients with glucose transporter type 1 syndrome may present with infantile seizures, developmental delay, acquired microcephaly ...
Rüya Çolak, Senem Alkan Özdemir, Ezgi Yangın Ergon, Mehtap Kağnıcı, Şebnem Çalkavur   +4 more
doaj   +1 more source

Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2019
Abstract Context Longstanding type 1 diabetes (T1D) may lead to alterations in hippocampal neurochemical profile. Upregulation of hippocampal glucose transport as a result of recurrent exposure to hypoglycemia may preserve cognitive function during future hypoglycemia in subjects with T1D and impaired
Petr Bednařík, Pierre-Gilles Henry, Amir Khowaja, Nathan Rubin, Anjali Kumar, Dinesh Deelchand, Lynn E Eberly, Elizabeth Seaquist, Gülin Öz, Amir Moheet   +9 more
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