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Beyond type 2 diabetes: sodium glucose co‐transporter‐inhibition in type 1 diabetes

Diabetes, Obesity and Metabolism, 2019
Use of sodium glucose cotransporter (SGLT) inhibitors are a well‐established therapeutic option in type 2 diabetes (T2D) with a variety of proven therapeutic benefits. They have become a pillar of current treatment guidelines. In type 1 diabetes (T1D), initial exploratory studies have shown benefits in glycemic control, weight control, and ...
Torben Biester   +2 more
openaire   +3 more sources

Glucose transporter type 1 deficiency: Ketogenic diet in three patients with atypical phenotype

Brain and Development, 2010
Glucose transporter type I deficiency syndrome (GLUT-1 DS) is an inborn error of glucose transport characterized by seizures, developmental delay, spasticity, acquired microcephaly and ataxia. Diagnosis is based on the finding of low cerebrospinal fluid glucose, in the absence of hypoglycemia, and identification of GLUT-1 gene mutation on chromosome 1.
Veggiotti P   +7 more
openaire   +3 more sources

Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1

Toxicology Letters, 2009
Dysglycemia and central nervous system (CNS) complications are the known adverse effects of fluoroquinolone antibiotics. Ciprofloxacin and levofloxacin are among the most prescribed antibiotics. In this study we demonstrate that ciprofloxacin and levofloxacin disturb glucose transport into HepG2 cells and such inhibition is associated with inhibited ...
Yuan-Yuan Ho   +3 more
openaire   +2 more sources

Perioperative Management of a Child With Glucose Transporter Type 1 Deficiency Syndrome: A Case Report

A&A Practice, 2018
Glucose transporter type 1 deficiency syndrome (GLUT1DS) causes central nervous system dysfunction including intractable epilepsy caused by impaired glucose transport to the brain. To prevent convulsions and maintain an energy source for the brain in patients with GLUT1DS, the maintenance of adequate ketone body concentrations, compensation of ...
Hiroshi Morimatsu   +4 more
openaire   +3 more sources

Ontogeny of the erythroid/HepG2-type glucose transporter (GLUT-1) in the rat nervous system

Developmental Brain Research, 1993
Central nervous system (CNS) microvessels of adult mammals have an unusually high density of the facilitative glucose transporter GLUT-1. Most systemic microvessels and those of the brain's circumventricular organs, which lack 'barrier' properties, do not express a high density of GLUT-1.
Sami I. Harik   +5 more
openaire   +3 more sources

Modified Atkins diet therapy for a case with glucose transporter type 1 deficiency syndrome

Brain and Development, 2008
Glucose transporter type 1 deficiency syndrome (GLUT-1 DS), giving rise to impaired glucose transport across the blood-brain barrier, is characterized by infantile seizures, complex motor disorders, global developmental delay, acquired microcephaly, and hypoglycorrhachia. GLUT-1 DS can be treated effectively with a ketogenic diet because it can provide
Keiko Ishigaki   +5 more
openaire   +3 more sources

Empagliflozin, a sodium glucose co-transporter 2 inhibitor, in the treatment of type 1 diabetes

Expert Opinion on Investigational Drugs, 2014
Available anti-hyperglycemic therapy in type 1 diabetes (T1DM) is currently restricted to insulin, pramlintide, and pancreas or islet cell transplantation. The imperfect replication of normal insulin secretion and glucose control has been a driver for development of other anti-hyperglycemic agents for this population. Empagliflozin, a sodium glucose co-
Elizabeth M. Lamos   +2 more
openaire   +3 more sources

Glucose Detection Devices and Methods Based on Metal–Organic Frameworks and Related Materials

Advanced Functional Materials, 2021
Kanwal Asif   +2 more
exaly  

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