Treatable GLUT 1 Deficiency Chorea Syndrome
Pediatric Neurology Briefs, 2010 A 7-year-old developmentally delayed girl with chorea and a glucose transporter type 1 (GLUT 1) deficiency syndrome is reported from Hospital Universitari Sant Joan de Deu, Barcelona, Spain, and University of Texas Southwestern Medical Centre, Dallas.
J Gordon Millichap
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FGT-1 is a mammalian GLUT2-like facilitative glucose transporter in Caenorhabditis elegans whose malfunction induces fat accumulation in intestinal cells. [PDF]
PLoS ONE, 2013 Caenorhabditis elegans (C. elegans) is an attractive animal model for biological and biomedical research because it permits relatively easy genetic dissection of cellular pathways, including insulin/IGF-like signaling (IIS), that are conserved in ...
Shun Kitaoka +2 more
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FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
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Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder [PDF]
, 2017 Glucose transporter-1 deficiency syndrome is caused by mutations in the SLC2A1 gene in the majority of patients and results in impaired glucose transport into the brain. From 2004-2008, 132 requests for mutational analysis of the SLC2A1 gene were studied
Arthur, Todd +52 more
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Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
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Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells [PDF]
, 2018 Cannabinoid 1 receptors (CB1Rs) are expressed in peripheral tissues, including islets of Langerhans, where their function(s) is under scrutiny. Using mouse beta-cell lines, human islets and CB1R-null (CB1R(-/-)) mice, we have now investigated the role of
Eun Kyung Lee +12 more
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FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Glucose Transporter 4 Expression in White Blood Cells of Young and Old Sled Dogs [PDF]
, 2012 Obesity has reached alarming levels in the United States Recent statistics show that 1 out of 3 individuals are either obese or overweight! The principle role of the hormone insulin is to mediate the redistribution of the glucose transporter- 4 (Glut4 ...
Schnurr, Theresia
core
Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid. [PDF]
, 2014 Hyperglycaemia as a result of diabetes mellitus or acute illness is associated with increased susceptibility to respiratory infection with Staphylococcus aureus.
A Brennan +50 more
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Journal of Nutrition and Metabolism, 2012 Atp10c is a strong candidate gene for diet-induced obesity and type 2 diabetes. To identify molecular and cellular targets of ATP10C, Atp10c expression was altered in vitro in C2C12 skeletal muscle myotubes by transient transfection with an Atp10c ...
S. E. Hurst +3 more
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