Results 11 to 20 of about 22,541 (119)

Implementation of dihydropyrimidine dehydrogenase deficiency testing in Europe

ESMO Open, 2023
Background The main cause for fluoropyrimidine-related toxicity is deficiency of the metabolizing enzyme dihydropyrimidine dehydrogenase (DPD). In 2020, the European Medicines Agency (EMA) recommended two methods for pre-treatment DPD deficiency testing ...
M. de With, A. Sadlon, E. Cecchin, V. Haufroid, F. Thomas, M. Joerger, R. V. van Schaik, R. Mathijssen, C. Largiadèr   +8 more
semanticscholar   +1 more source

The enzymopathy of G6PD deficiency in Jordan: a demographic and biochemical analysis

Asian Journal of Medical Sciences, 2018
Background: G6PD deficiency is an inherited X-linked recessive condition leading to insufficient levels of glucose-6-phosphate dehydrogenase, thus causing hemolytic anaemia under certain circumstances.
Ahmed Al-Imam
doaj   +1 more source

Icterícia neonatal e deficiência de glicose-6-fosfato desidrogenase Neonatal jaundice and glucose-6-phosphate dehydrogenase

Revista Brasileira de Hematologia e Hemoterapia, 2010
A deficiência de glicose-6-fosfato desidrogenase em neonatos pode ser a responsável pela icterícia neonatal. Este comentário científico é decorrente do relato sobre o tema publicado neste fascículo e que preocupa diversos autores de outros países em ...
Amauri Antiquera Leite
doaj   +1 more source

Deficiência da glicose-6-fosfato desidrogenase com infecções de repetição: relato de caso Glucose-6-phosphate dehydrogenase deficiency with recurrent infections: case report

Jornal de Pediatria, 2001
OBJETIVO: relatar a ocorrência de uma deficiência funcional de neutrófilos rara, com quadro clínico e laboratorial semelhante ao da doença granulomatosa crônica.
Abertina Rosa-Borges, Márcia G. Sampaio, Antônio Condino-Neto, Orlando C.O. Barreto, Victor Nudelman, Magda M.S. Carneiro-Sampaio, Susie A. Nogueira, Thalita F. de Abreu, Jussara Rehder, Beatriz T. Costa-Carvalho   +9 more
doaj   +1 more source

Investigação genético-epidemiológica e molecular da deficiência de G-6-PD em uma comunidade brasileira G-6-PD deficiency in a Brazilian community: an investigation involving epidemiological genetics and molecular techniques

Cadernos de Saúde Pública, 2000
Este trabalho teve por objetivo estudar a deficiência de G-6-PD em uma comunidade do interior do Estado de São Paulo (Bragança Paulista). Durante 36 meses foram selecionados 4.621 doadores de sangue do sexo masculino, detectando-se 80 deficientes em G-6 ...
Mariane B. Compri, Sara T. O. Saad, Antonio Sérgio Ramalho   +2 more
doaj   +1 more source

The severity of acute viral hepatitis in patients with glucose-6-phosphate dehydrogenase deficiency: a case-control study

Journal of the Pakistan Medical Association
Objectives: To compare outcomes and severity parameters in patients with acute viral hepatitis and those with acute viral hepatitis and glucose-6-phosphate dehydrogenase deficiency.
Mahrukh Ali, Omair Ayaz, Zara Ghos, Om Parkash   +3 more
doaj   +1 more source

Cytotoxicity and toxicoproteomics analysis of thiazolidinedione exposure in human‐derived cardiomyocytes

Journal of Applied Toxicology, Volume 44, Issue 8, Page 1214-1235, August 2024.
Abstract Thiazolidinediones (TZDs) (e.g. pioglitazone and rosiglitazone), known insulin sensitiser agents for type II diabetes mellitus, exhibit controversial effects on cardiac tissue. Despite consensus on their association with increased heart failure risk, limiting TZD use in diabetes management, the underlying mechanisms remain uncharacterised ...
Abdullah Al Sultan, Zahra Rattray, Nicholas J. W. Rattray   +2 more
wiley   +1 more source

Scrub Typhus Infection Precipitating Hemolysis in a Patient With G6PD Deficiency: A Case Report

Clinical Case Reports
Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is a well‐known red blood cell enzymopathy and a cause of intravascular hemolysis. This case report presents a child with underlying G6PD deficiency who experienced an acute episode of extensive ...
Ravi Shukla, Mandira Shrestha, Chaitanya Darshan Bhattarai, Kiran Lamichhane, Paras Yadav, Debendra Tamatta   +5 more
doaj   +1 more source

Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation

Nature Communications
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on ...
Yifan Chen, Miao Xian, Wen-wen Ying, Jiayi Liu, Shaowei Bing, Xiaomin Wang, Jiayi Yu, Xiaojun Xu, Sen-feng Xiang, Xuejing Shao, Ji Cao, Qiaojun He, Bo Yang, Meidan Ying   +13 more
semanticscholar   +1 more source

Bioinformatic analysis of G6PD variants with a focus on key Iranian mutations [PDF]

Journal of Clinical and Basic Research
Background: Glucose-6-phosphate dehydrogenase deficiency, an enzyme disorder, can lead to red blood cell dysfunction and affect millions of individuals worldwide.
Romina Jafari Kalokan, Sepide Sharifi Tabar, Morteza Oladnabi   +2 more
doaj