Results 151 to 160 of about 87,618 (315)
Drug Design, Development and Therapy, 2015 Valérie Brunner,1 Bernadette Maynadier,2 Laishun Chen,3 Louise Roques,2 Isabelle Hude,2 Sébastien Séguier,2 Laurence Barthe,1 Philippe Hermann11Pierre Fabre Médicament, Centre de R&D, Toulouse, 2Centre Experimental ...
Brunner V +7 more
doaj
Identification of Metabolites of the Dietary Supplement Ingredient 5α‐Hydroxy‐Laxogenin
Drug Testing and Analysis, Volume 18, Issue 4, Page 483-489, April 2026.The biotransformation of the dietary supplement ingredient 5α‐hydroxy‐laxogenin was investigated using human HepG2 cells, the rat and in silico using the online software Next‐gen E‐Resource for Drug Discovery (NERDD). We identified five metabolites generated by the human HepG2 cells of which three and an additional mono‐hydroxylated metabolite were ...
Daniel Derwand +3 more
wiley +1 more source
Polycyclic aromatic hydrocarbons and esophageal squamous cell carcinoma [PDF]
, 2012 Esophageal cancer (EC) is the 8th most common cancer and the 6th most frequent cause of cancer mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common type of EC.
Dawsey, S.M. +3 more
core
eFood, Volume 7, Issue 2, April 2026.Composition, biological activity and food application of banana biomass. ABSTRACT The global banana processing industry generates substantial organic waste in the form of peels, leaves, stems, and flowers, posing both environmental challenges and opportunities for valorization within a circular economy framework.
Bushra Iram Fatima +8 more
wiley +1 more source
Results in ChemistryThe epidermal growth factor receptor (EGFR) is a transmembrane protein that plays a pivotal role in cellular signaling. EGFR dysregulation is critically associated with oncogenic signaling cascade, establishing it as a prime target for cancer ...
Aswin Mohan +2 more
doaj +1 more source
eFood, Volume 7, Issue 2, April 2026.An integrative approach of network pharmacology, molecular docking, and MSC proliferation confirmation was performed to elucidate the mechanism of SSG in treating osteoporosis. Fewer free isoflavones but more glucuronide metabolites were detected in plasma.
Rezeye Aili, Hong Chen, Feng Qiu
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.This study evaluated KDZ aqueous extract's therapeutic potential for MI/RI and investigated its mechanism. In a mouse MI/RI model, the aqueous extract mitigated injury and preserved cardiac function. Liquid chromatography‐mass spectrometry (LC–MS) identified eighty‐six components. Based on Compound‐target‐disease interaction network and KEGG enrichment
Xiaoxia Tian +7 more
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 4, April 2026.Abstract Atomoxetine, a selective norepinephrine reuptake inhibitor, is a nonstimulant alternative to treat attention‐deficit/hyperactivity disorder in children and adolescents. Atomoxetine exposure is highly variable due to cytochrome P450 polymorphism; however, the impact of these genetic variations has not been adequately characterized in the ...
Kevin. V. Tobin +4 more
wiley +1 more source