Results 21 to 30 of about 87,618 (315)

Quantitative Determination of Common Urinary Odorants and Their Glucuronide Conjugates in Human Urine

Metabolites, 2013
Our previous study on the identification of common odorants and their conjugates in human urine demonstrated that this substance fraction is a little-understood but nonetheless a promising medium for analysis and diagnostics in this easily accessible ...
Maria Wagenstaller, Andrea Buettner
doaj   +1 more source

Synthesis, Structural Elucidation, and Anti-Inflammatory Activity of a Water-Soluble Derivative of Arctiin

Molecules, 2023
The poor oral bioavailability of arctiin caused by its low water solubility is the biggest obstacle in developing it as a drug. In this work, a new water-soluble glucuronide derivative of arctiin (arctigenin-4′-O-glucuronide) was synthesized through 2,2 ...
Xia Xu, Xiaofeng Huang, Yuedan Zheng, Xiaoling Wang, Jing Xie, Sha Liu, Kun Guo   +6 more
doaj   +1 more source

Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a 13C-tracer study [PDF]

, 2013
BACKGROUND: Evidence suggests that the consumption of anthocyanin-rich foods beneficially affects cardiovascular health; however, the absorption, distribution, metabolism, and elimination (ADME) of anthocyanin-rich foods are relatively unknown. OBJECTIVE:
Aedín Cassidy, Cassidy, Charles Czank, Colin D Kay, Das, Das, de Pascual-Teresa, Del Bò, Del Rio, Douglas J Morrison, Felgines, Felgines, Felgines, Garcia-Alonso, González-Barrio, Haycock, Hooper, Ichiyanagi, Kay, Kay, Kay, Manach, Mazza, McCullough, Milbury, Mink, Miyazawa, Morrison, Morrison, Morrison, Mullen, Neveu, Nigel P Botting, Nurmi, Paul A Kroon, Qingzhi Zhang, Shreeve, Slater, Tom Preston, Tsuda, Ueno, Vitaglione, Wallace, Walle, Williamson, Williamson, Woodward, Wu, Zhang, Zhang, Zhang   +50 more
core   +1 more source

Synthesis and stability study of a new major metabolite of γ-hydroxybutyric acid

Beilstein Journal of Organic Chemistry, 2013
γ-Hydroxybutanoic acid (GHB) is used as a date-rape drug, which renders the victims unconscious and defenceless. Intoxications are very difficult to detect for forensic scientists due to rapid metabolism to endogenous levels of GHB.
Ida Nymann Petersen, Jesper Langgaard Kristensen, Christian Tortzen, Torben Breindahl, Daniel Sejer Pedersen   +4 more
doaj   +1 more source

Development and Validation of a Method for Determining the Quercetin-3-O-glucuronide and Ellagic Acid Content of Common Evening Primrose (Oenothera biennis) by HPLC-UVD

Molecules, 2021
Toward the standardization of common evening primrose (Oenothera biennis) sprout extract (OBS-E), we aimed to obtain indicator compounds and use a validated method.
Tae Heon Kim, Hyun Young Shin, Soon Yeong Park, Hoon Kim, Dae Kyun Chung   +4 more
doaj   +1 more source

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]

, 2020
Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher, Dorrestein, Pieter C, Jarmusch, Alan K, Knight, Rob, Liyanage, Marlon, Ma, Joseph D, Momper, Jeremiah D, Tsunoda, Shirley M, Vrbanac, Alison   +8 more
core   +1 more source

Antinociceptive Effect of Single Components Isolated from Agrimonia pilosa Ledeb. Extract

Scientia Pharmaceutica, 2019
Agrimonia pilosa Ledeb. produces an antinociceptive effect in ICR mice in both chemically induced and thermal pain models. In the present study, we examined the antinociceptive effects of single components isolated from Agrimonia pilosa Ledeb.
Jing Hui Feng, Hee Jung Lee, Set Byeol Kim, Jeon Sub Jung, Soon Sung Lim, Hong Won Suh   +5 more
doaj   +1 more source

Trace quantification of GL-V9 and its glucuronide metabolites (5-O-glucuronide GL-V9) in Beagle dog plasma by UPLC-MS/MS and its application to a pharmacokinetic study.

PLoS ONE, 2023
GL-V9, a new synthetic flavonoid derived from wogonin, has shown beneficial biological functions. In this study, accurate and sensitive UPLC-MS/MS methods were developed and validated for the quantification of GL-V9 and its glucuronide metabolite (5-O ...
Xuefeng Zhang, Guanlan Liu, Zechun Sang, Qinglong Guo, Yuxin Zhou   +4 more
doaj   +1 more source

Clinical Study to Evaluate Drug Interactions of Cannabidiol with Citalopram and Morphine in Healthy Adults. [PDF]

Clin Pharmacol Ther
Cannabidiol (CBD) is one of the most abundant bioactive cannabinoids. Research has demonstrated CBD’s ability to inhibit metabolic enzymes like cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT), potentially leading to drug interactions. However, clinical knowledge gaps remain, particularly with regard to drugs that are more commonly taken by ...
Salcedo P, Volpe DA, Chaturbedi A, Shah A, Krishna A, Hyland PL, Vegesna G, Hsiao CH, De Palma R, Fein M, Rouse R, Florian J.   +11 more
europepmc   +2 more sources

Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice. [PDF]

, 2017
Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues.
Brenner, Stefan, Böhmdorfer, Michaela, Jäger, Walter, Riha, Juliane, Schiestl, Robert H, Szakmary, Akos, Szekeres, Thomas, Thalhammer, Theresia, Vaquero, Javier   +8 more
core   +2 more sources